KQL49633.1 protein (Brevibacillus choshinensis)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

Node Content

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proteins of unknown 3D structure

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a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

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[Homology]

Score

KQL49633.1

Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (227 aa)

Predicted Functional Partners:

KQL49622.1

0.530

KQL49632.1

0.515

KQL49496.1

0.472

KQL47113.1

0.410

KQL49652.1

0.404

Your Current Organism:

Brevibacillus choshinensis

NCBI taxonomy Id: 54911
Other names: ATCC 51359, B. choshinensis, Bacillus choshinensis, CIP 103838, DSM 8552, IFO 15518, JCM 8505, LMG 15968, LMG:15968, NBRC 15518, NCIMB 13345, NRRL B-23247, strain HPD52

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
KQL47113.1	KQL49633.1	AN963_19975	AN963_07875	Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
KQL49496.1	KQL49633.1	AN963_07060	AN963_07875	Permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
KQL49622.1	KQL49633.1	AN963_07810	AN963_07875	MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.530
KQL49632.1	KQL49633.1	AN963_07870	AN963_07875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.515
KQL49633.1	KQL47113.1	AN963_07875	AN963_19975	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Multidrug transporter; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.410
KQL49633.1	KQL49496.1	AN963_07875	AN963_07060	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Permease; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.472
KQL49633.1	KQL49622.1	AN963_07875	AN963_07810	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	MerR family transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.530
KQL49633.1	KQL49632.1	AN963_07875	AN963_07870	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.515
KQL49633.1	KQL49652.1	AN963_07875	AN963_07985	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.404
KQL49652.1	KQL49633.1	AN963_07985	AN963_07875	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.	0.404

Network Stats

number of nodes:

11

number of edges:

13

average node degree:

2.36

avg. local clustering coefficient:

0.915

expected number of edges:

11

PPI enrichment p-value:

0.26

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
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Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009401

Phosphoenolpyruvate-dependent sugar phosphotransferase system

4 of 5

2.48

2.84

4.13e-06

GO:0006355

Regulation of transcription, DNA-templated

7 of 236

1.05

1.03

0.00010

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008982

protein-N(PI)-phosphohistidine-sugar phosphotransferase activity

2 of 2

2.58

1.03

0.0131

GO:0003677

DNA binding

7 of 353

0.87

0.63

0.0058

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2526

Periplasmic binding protein-like domain, and Phosphotransferase system (PTS)

10 of 17

2.35

8.19

1.85e-19

CL:2529

Phosphotransferase system (PTS), and Periplasmic binding protein-like domain

6 of 10

2.35

4.96

6.17e-11

CL:2425

Carbohydrate metabolic process, and Transcriptional regulator LacI/GalR-like, sensor domain

11 of 85

1.69

4.25

2.34e-16

CL:2531

Phosphotransferase system (PTS)

4 of 5

2.48

3.37

3.50e-07

CL:2550

Amine-lyase activity, and LacI-type HTH domain

3 of 5

2.35

2.18

7.18e-05

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map02060

Phosphotransferase system (PTS)

4 of 7

2.33

3.05

1.11e-06

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0032993

protein-DNA complex

7 of 59

1.65

2.77

1.64e-08

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0598

Phosphotransferase system

3 of 3

2.58

1.52e-05

KW-0805

Transcription regulation

7 of 113

1.37

1.82

9.29e-07

KW-0238

DNA-binding

7 of 178

1.17

1.35

6.45e-06

KW-0762

Sugar transport

2 of 4

2.28

1.27

0.0042

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF13377

Periplasmic binding protein-like domain

6 of 8

2.45

4.97

1.16e-10

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR046335

Transcriptional regulator LacI/GalR-like, sensor domain

7 of 9

2.47

5.85

1.34e-12

IPR028082

Periplasmic binding protein-like I

7 of 12

2.34

5.49

2.95e-12

IPR000843

LacI-type HTH domain

5 of 8

2.37

3.81

2.89e-08

IPR010982

Lambda repressor-like, DNA-binding domain superfamily

5 of 26

1.86

2.48

2.80e-06

IPR033532

Arabinose metabolism transcriptional repressor, ligand-binding domain

2 of 2

2.58

1.06

0.0116

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00354

Helix_turn _helix lactose operon repressor

5 of 8

2.37

4.09

6.95e-09

SM00345

Helix_turn_helix gluconate operon transcriptional repressor

2 of 12

1.8

0.76

0.0347

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