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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
KZE48566.1PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology. (472 aa)    
Predicted Functional Partners:
KZE49441.1
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 
 0.952
spo0A
Sporulation transcription factor Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with Spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process. Repressor of abrB, activator of the spoIIa operon. Binds the DNA sequence 5'-TGNCGAA-3' (0A box) (By similarity).
  
  
 0.825
KZE55794.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.772
KZE48758.1
PAS domain-containing sensor histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
 
0.738
KZE39229.1
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.731
resD_2
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
  0.725
AV540_12425
Hypothetical protein; Incomplete; partial in the middle of a contig; missing stop; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
  0.713
KZE43438.1
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.709
KZE50070.1
Two-component system response regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
  0.697
KZE48767.1
Histidine kinase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
  
  0.694
Your Current Organism:
Brevibacillus parabrevis
NCBI taxonomy Id: 54914
Other names: ATCC 10027, B. parabrevis, Bacillus parabrevis, CIP 103840, DSM 8376, IFO 12334, JCM 8506, LMG 15971, LMG:15971, NBRC 12334, NCIMB 13346, NRRL NRS-605, NRRL NRS-815
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.