Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
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[Homology]
Score
KNB74158.1Membrane protein; Derived by automated computational analysis using gene prediction method: Protein Homology. (118 aa)    
Predicted Functional Partners:
KNB73680.1
Alkaline phosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.773
topB
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
 
     0.528
KNB73679.1
DNA alkylation repair protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.459
KNB74103.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the GTP cyclohydrolase I type 2/NIF3 family.
       0.448
KNB73681.1
Spore gernimation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.436
KNB73682.1
Spore gernimation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.436
KNB73683.1
Spore gernimation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.436
KNB73678.1
Fe-S oxidoreductase; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.423
KNB73684.1
Spore gernimation protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.421
Your Current Organism:
Brevibacillus reuszeri
NCBI taxonomy Id: 54915
Other names: ATCC 51665, B. reuszeri, Bacillus reuszeri, CIP 104543, DSM 9887, IFO 15719, JCM 9170, LMG 16012, LMG:16012, NBRC 15719, strain H.W. Reuszer Army strain 39
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