node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCY20369.1 | SCY20412.1 | SAMN02927923_00837 | SAMN02927923_00838 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hypothetical protein. | 0.561 |
SCY20369.1 | SCY27755.1 | SAMN02927923_00837 | SAMN02927923_01031 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Phosphotransferase system, enzyme I, PtsP; Belongs to the PEP-utilizing enzyme family. | 0.623 |
SCY20369.1 | SCY84625.1 | SAMN02927923_00837 | SAMN02927923_02572 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Porphobilinogen synthase; Belongs to the ALAD family. | 0.963 |
SCY20369.1 | hemC | SAMN02927923_00837 | SAMN02927923_00836 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.992 |
SCY20369.1 | hemE | SAMN02927923_00837 | SAMN02927923_01312 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.783 |
SCY20369.1 | hemH | SAMN02927923_00837 | SAMN02927923_03496 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.440 |
SCY20369.1 | tsaD | SAMN02927923_00837 | SAMN02927923_00835 | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | N6-L-threonylcarbamoyladenine synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.689 |
SCY20412.1 | SCY20369.1 | SAMN02927923_00838 | SAMN02927923_00837 | Hypothetical protein. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.561 |
SCY20412.1 | hemC | SAMN02927923_00838 | SAMN02927923_00836 | Hypothetical protein. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.732 |
SCY20412.1 | tsaD | SAMN02927923_00838 | SAMN02927923_00835 | Hypothetical protein. | N6-L-threonylcarbamoyladenine synthase; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction; Belongs to the KAE1 / TsaD family. | 0.462 |
SCY27755.1 | SCY20369.1 | SAMN02927923_01031 | SAMN02927923_00837 | Phosphotransferase system, enzyme I, PtsP; Belongs to the PEP-utilizing enzyme family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.623 |
SCY27755.1 | hemC | SAMN02927923_01031 | SAMN02927923_00836 | Phosphotransferase system, enzyme I, PtsP; Belongs to the PEP-utilizing enzyme family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.645 |
SCY46489.1 | hemC | SAMN02927923_01378 | SAMN02927923_00836 | Fe-S cluster biogenesis protein NfuA, 4Fe-4S-binding domain. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.567 |
SCY84625.1 | SCY20369.1 | SAMN02927923_02572 | SAMN02927923_00837 | Porphobilinogen synthase; Belongs to the ALAD family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.963 |
SCY84625.1 | hemC | SAMN02927923_02572 | SAMN02927923_00836 | Porphobilinogen synthase; Belongs to the ALAD family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.995 |
SCY84625.1 | hemE | SAMN02927923_02572 | SAMN02927923_01312 | Porphobilinogen synthase; Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.734 |
SCY84625.1 | hemH | SAMN02927923_02572 | SAMN02927923_03496 | Porphobilinogen synthase; Belongs to the ALAD family. | Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family. | 0.504 |
SCY89700.1 | hemC | SAMN02927923_02759 | SAMN02927923_00836 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | 0.565 |
SCY89700.1 | xseB | SAMN02927923_02759 | SAMN02927923_02798 | Octaprenyl-diphosphate synthase; Belongs to the FPP/GGPP synthase family. | Exodeoxyribonuclease VII small subunit; Bidirectionally degrades single-stranded DNA into large acid- insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides; Belongs to the XseB family. | 0.636 |
hemC | SCY20369.1 | SAMN02927923_00836 | SAMN02927923_00837 | Hydroxymethylbilane synthase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. | uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. | 0.992 |