node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SCY78331.1 | SCZ12997.1 | SAMN02927923_02258 | SAMN02927923_04397 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | dCTP deaminase. | 0.659 |
SCY78331.1 | dut | SAMN02927923_02258 | SAMN02927923_01518 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.902 |
SCY78331.1 | ndk | SAMN02927923_02258 | SAMN02927923_00132 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.843 |
SCY78331.1 | thyA | SAMN02927923_02258 | SAMN02927923_02020 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.837 |
SCY78331.1 | tmk | SAMN02927923_02258 | SAMN02927923_02450 | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.763 |
SCY82171.1 | SCY82205.1 | SAMN02927923_02449 | SAMN02927923_02451 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6); Belongs to the peptidase S11 family. | DNA polymerase-3 subunit delta'. | 0.793 |
SCY82171.1 | tmk | SAMN02927923_02449 | SAMN02927923_02450 | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6); Belongs to the peptidase S11 family. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.791 |
SCY82205.1 | SCY82171.1 | SAMN02927923_02451 | SAMN02927923_02449 | DNA polymerase-3 subunit delta'. | D-alanyl-D-alanine carboxypeptidase (penicillin-binding protein 5/6); Belongs to the peptidase S11 family. | 0.793 |
SCY82205.1 | tmk | SAMN02927923_02451 | SAMN02927923_02450 | DNA polymerase-3 subunit delta'. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.821 |
SCZ12997.1 | SCY78331.1 | SAMN02927923_04397 | SAMN02927923_02258 | dCTP deaminase. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.659 |
SCZ12997.1 | dut | SAMN02927923_04397 | SAMN02927923_01518 | dCTP deaminase. | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.731 |
SCZ12997.1 | ndk | SAMN02927923_04397 | SAMN02927923_00132 | dCTP deaminase. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.733 |
SCZ12997.1 | pyrE | SAMN02927923_04397 | SAMN02927923_00232 | dCTP deaminase. | Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.425 |
SCZ12997.1 | tdk | SAMN02927923_04397 | SAMN02927923_00909 | dCTP deaminase. | Thymidine kinase. | 0.704 |
SCZ12997.1 | thyA | SAMN02927923_04397 | SAMN02927923_02020 | dCTP deaminase. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.738 |
SCZ12997.1 | tmk | SAMN02927923_04397 | SAMN02927923_02450 | dCTP deaminase. | dTMP kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.777 |
dut | SCY78331.1 | SAMN02927923_01518 | SAMN02927923_02258 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Ribonucleoside-diphosphate reductase class II; Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. | 0.902 |
dut | SCZ12997.1 | SAMN02927923_01518 | SAMN02927923_04397 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | dCTP deaminase. | 0.731 |
dut | ndk | SAMN02927923_01518 | SAMN02927923_00132 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.884 |
dut | tdk | SAMN02927923_01518 | SAMN02927923_00909 | Deoxyuridine 5'-triphosphate nucleotidohydrolase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidine kinase. | 0.925 |