SIT87212.1 protein (Edaphobacillus lindanitolerans)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

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protein homology

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Score

SIT87212.1

SagB-type dehydrogenase domain-containing protein. (243 aa)

Predicted Functional Partners:

SIT87209.1

0.985

SIT87211.1

0.950

SIT87207.1

0.946

SIT87206.1

0.850

SIT87210.1

0.777

SIT87208.1

0.773

SIT87205.1

0.761

SIT87213.1

0.746

SIT87204.1

0.740

birA

0.635

Your Current Organism:

Edaphobacillus lindanitolerans

NCBI taxonomy Id: 550447
Other names: Bacillus sp. MNA4, CCM 7584, DSM 22424, E. lindanitolerans, strain MNA4

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
SIT87204.1	SIT87205.1	SAMN05428946_2009	SAMN05428946_2010	Hypothetical protein.	Lantibiotic dehydratase, C terminus.	0.781
SIT87204.1	SIT87206.1	SAMN05428946_2009	SAMN05428946_2011	Hypothetical protein.	ABC-2 type transport system ATP-binding protein.	0.773
SIT87204.1	SIT87207.1	SAMN05428946_2009	SAMN05428946_2012	Hypothetical protein.	ABC-2 type transport system permease protein.	0.773
SIT87204.1	SIT87208.1	SAMN05428946_2009	SAMN05428946_2013	Hypothetical protein.	Hypothetical protein.	0.737
SIT87204.1	SIT87209.1	SAMN05428946_2009	SAMN05428946_2014	Hypothetical protein.	Ribosomal protein S12 methylthiotransferase accessory factor.	0.745
SIT87204.1	SIT87210.1	SAMN05428946_2009	SAMN05428946_2015	Hypothetical protein.	Hypothetical protein.	0.744
SIT87204.1	SIT87211.1	SAMN05428946_2009	SAMN05428946_2016	Hypothetical protein.	Thiopeptide-type bacteriocin biosynthesis domain-containing protein.	0.742
SIT87204.1	SIT87212.1	SAMN05428946_2009	SAMN05428946_2017	Hypothetical protein.	SagB-type dehydrogenase domain-containing protein.	0.740
SIT87204.1	SIT87213.1	SAMN05428946_2009	SAMN05428946_2018	Hypothetical protein.	Hypothetical protein.	0.711
SIT87205.1	SIT87204.1	SAMN05428946_2010	SAMN05428946_2009	Lantibiotic dehydratase, C terminus.	Hypothetical protein.	0.781
SIT87205.1	SIT87206.1	SAMN05428946_2010	SAMN05428946_2011	Lantibiotic dehydratase, C terminus.	ABC-2 type transport system ATP-binding protein.	0.773
SIT87205.1	SIT87207.1	SAMN05428946_2010	SAMN05428946_2012	Lantibiotic dehydratase, C terminus.	ABC-2 type transport system permease protein.	0.786
SIT87205.1	SIT87208.1	SAMN05428946_2010	SAMN05428946_2013	Lantibiotic dehydratase, C terminus.	Hypothetical protein.	0.737
SIT87205.1	SIT87209.1	SAMN05428946_2010	SAMN05428946_2014	Lantibiotic dehydratase, C terminus.	Ribosomal protein S12 methylthiotransferase accessory factor.	0.796
SIT87205.1	SIT87210.1	SAMN05428946_2010	SAMN05428946_2015	Lantibiotic dehydratase, C terminus.	Hypothetical protein.	0.746
SIT87205.1	SIT87211.1	SAMN05428946_2010	SAMN05428946_2016	Lantibiotic dehydratase, C terminus.	Thiopeptide-type bacteriocin biosynthesis domain-containing protein.	0.902
SIT87205.1	SIT87212.1	SAMN05428946_2010	SAMN05428946_2017	Lantibiotic dehydratase, C terminus.	SagB-type dehydrogenase domain-containing protein.	0.761
SIT87205.1	SIT87213.1	SAMN05428946_2010	SAMN05428946_2018	Lantibiotic dehydratase, C terminus.	Hypothetical protein.	0.711
SIT87206.1	SIT87204.1	SAMN05428946_2011	SAMN05428946_2009	ABC-2 type transport system ATP-binding protein.	Hypothetical protein.	0.773
SIT87206.1	SIT87205.1	SAMN05428946_2011	SAMN05428946_2010	ABC-2 type transport system ATP-binding protein.	Lantibiotic dehydratase, C terminus.	0.773

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

24

average node degree:

4.36

avg. local clustering coefficient:

0.792

expected number of edges:

18

PPI enrichment p-value:

0.11

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006304

DNA modification

6 of 19

2.18

3.98

3.51e-09

GO:0009307

DNA restriction-modification system

4 of 10

2.28

2.69

5.58e-06

GO:0044419

Biological process involved in interspecies interaction between organisms

5 of 35

1.83

2.34

5.58e-06

GO:0009605

Response to external stimulus

5 of 47

1.7

2.17

6.22e-06

GO:0006259

DNA metabolic process

7 of 192

1.24

1.46

6.21e-06

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003677

DNA binding

7 of 337

0.99

0.84

0.00093

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:1905347

Endodeoxyribonuclease complex

5 of 9

2.42

4.21

4.66e-09

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:9050

Mixed, incl. DNA modification, and Nucleotidyltransferase domain

9 of 37

2.06

5.62

7.75e-15

CL:9055

DNA modification, and Ribosomal large subunit binding

6 of 14

2.31

4.72

1.62e-10

CL:9107

Nucleotidyltransferase domain, and Domain of unknown function DUF2281

3 of 5

2.45

2.22

6.64e-05

CL:9058

Type I restriction modification DNA specificity domain, and DNA methylation on adenine

3 of 5

2.45

2.22

6.64e-05

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:1905347

Endodeoxyribonuclease complex

2 of 7

2.13

0.99

0.0141

GOCC:1902494

Catalytic complex

6 of 220

1.11

0.98

0.00070

GOCC:0032991

Protein-containing complex

8 of 626

0.78

0.65

0.00078

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0540

Nuclease

3 of 44

1.51

0.78

0.0235

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01420

Type I restriction modification DNA specificity domain

3 of 3

2.68

2.19

9.07e-05

PF04313

Type I restriction enzyme R protein N terminus (HSDR_N)

2 of 2

2.68

1.16

0.0079

PF01909

Nucleotidyltransferase domain

2 of 6

2.2

0.87

0.0245

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR044946

Type I restriction modification DNA specificity domain superfamily

3 of 3

2.68

1.98

0.00023

IPR000055

Type I restriction modification DNA specificity domain

3 of 3

2.68

1.98

0.00023

IPR014001

Helicase superfamily 1/2, ATP-binding domain

3 of 20

1.85

1.1

0.0067

IPR007409

Restriction endonuclease, type I, HsdR, N-terminal

2 of 2

2.68

1.1

0.0101

IPR006935

Helicase/UvrB, N-terminal

2 of 6

2.2

0.77

0.0375

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00487

DEAD-like helicases superfamily

3 of 17

1.92

1.5

0.0010

SM00490

Helicase superfamily c-terminal domain

2 of 13

1.86

0.81

0.0277

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