STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
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[Homology]
Score
pyrEOrotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). (213 aa)    
Predicted Functional Partners:
pyrD
Dihydroorotate oxidase A; Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
  
 0.992
pyrF
Orotidine-5'-phosphate decarboxylase; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
  
 
 0.992
carB
COGs: COG0458 Carbamoylphosphate synthase large subunit (split gene in MJ); InterPro IPR005483: IPR003135: IPR005479: IPR003806: IPR 011607: IPR005480: IPR005481: IPR011761: IPR006275; KEGG: slo:Shew_2838 carbamoyl phosphate synthase large subunit; PFAM: Carbamoyl-phosphate synthase L chain ATP-binding; ATP-dependent carboxylate-amine ligase domain protein ATP-grasp; protein of unknown function DUF201; MGS domain protein; Carbamoyl-phosphate synthetase large chain oligomerisation; Carbamoyl-phosphate synthetase large chain domain protein; SPTR: A2UYB9 Carbamoyl-phosphate synthase, larg [...]
  
 
 0.930
pyrB
COGs: COG0540 Aspartate carbamoyltransferase catalytic chain; InterPro IPR006130: IPR002082: IPR002292: IPR006132: IPR 006131; KEGG: vsp:VS_2740 aspartate carbamoyltransferase catalytic subunit; PFAM: aspartate/ornithine carbamoyltransferase carbamoyl-P binding domain; aspartate/ornithine carbamoyltransferase Asp/Orn-binding region; SPTR: A3UTH1 Aspartate carbamoyltransferase catalytic subunit; TIGRFAM: aspartate carbamoyltransferase; PFAM: Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domain; Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain; TIGRFAM: as [...]
  
  
 0.925
carA
COGs: COG0505 Carbamoylphosphate synthase small subunit; InterPro IPR006220: IPR011702: IPR001317: IPR002474: IPR 000991: IPR006274; KEGG: saz:Sama_2504 carbamoyl phosphate synthase small subunit; PFAM: Carbamoyl-phosphate synthase small chain; glutamine amidotransferase class-I; SPTR: Q8EHS6 Carbamoyl-phosphate synthase small chain; TIGRFAM: carbamoyl-phosphate synthase, small subunit; PFAM: Carbamoyl-phosphate synthase small chain, CPSase domain; Glutamine amidotransferase class-I; TIGRFAM: carbamoyl-phosphate synthase, small subunit; Belongs to the CarA family.
  
  
 0.919
Fbal_3571
Oxidoreductase FAD/NAD(P)-binding domain protein; COGs: COG0543 2-polyprenylphenol hydroxylase and related flavodoxin oxidoreductase; InterPro IPR001709: IPR001221: IPR008333: IPR001433; KEGG: son:SO_0504 FMN reductase; PFAM: oxidoreductase FAD/NAD(P)-binding domain protein; Oxidoreductase FAD-binding domain protein; SPTR: A2UUW9 Oxidoreductase FAD/NAD(P)-binding; PFAM: Oxidoreductase FAD-binding domain; Oxidoreductase NAD-binding domain.
  
  
 0.919
Fbal_1256
COGs: COG2233 Xanthine/uracil permease; InterPro IPR004711: IPR006043: IPR006042; KEGG: sfr:Sfri_1749 uracil-xanthine permease; PFAM: Xanthine/uracil/vitamin C permease; Benzoate membrane transport protein; SPTR: A2V5E9 Uracil-xanthine permease; TIGRFAM: uracil-xanthine permease; PFAM: Permease family; TIGRFAM: uracil-xanthine permease.
  
  
 0.906
Fbal_1619
Amidohydrolase; COGs: COG0044 Dihydroorotase and related cyclic amidohydrolase; InterPro IPR006680: IPR002195; KEGG: aha:AHA_2602 dihydroorotase; PFAM: amidohydrolase; SPTR: A2TV48 Dihydroorotase; PFAM: Amidohydrolase family; TIGRFAM: dihydroorotase, multifunctional complex type.
  
  
 0.892
Fbal_2247
Isoaspartyl dipeptidase; Catalyzes the hydrolytic cleavage of a subset of L- isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation. Belongs to the peptidase M38 family.
  
  
 0.892
prs
Ribose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.
  
 
 0.867
Your Current Organism:
Ferrimonas balearica
NCBI taxonomy Id: 550540
Other names: F. balearica DSM 9799, Ferrimonas balearica DSM 9799, Ferrimonas balearica PAT, Ferrimonas balearica str. DSM 9799, Ferrimonas balearica strain DSM 9799
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