STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Fbal_1990Isocitrate dehydrogenase, NADP-dependent; COGs: COG0538 Isocitrate dehydrogenase; InterPro IPR001804: IPR019818: IPR004439; KEGG: pmr:PMI0891 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: P08200 Isocitrate dehydrogenase [NADP]; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, prokaryotic type. (417 aa)    
Predicted Functional Partners:
Fbal_0376
Aconitase; COGs: COG1049 Aconitase B; InterPro IPR015929: IPR001030: IPR018136: IPR004406; KEGG: vpa:VP2495 bifunctional aconitate hydratase 2/2-methylisocitrate dehydratase; PFAM: Aconitase B, N-terminal; aconitate hydratase domain protein; SPTR: A3H377 Aconitate hydratase 2; TIGRFAM: aconitate hydratase 2; PFAM: Aconitate B N-terminal domain; Aconitase family (aconitate hydratase); Aconitate hydratase 2 N-terminus; TIGRFAM: aconitate hydratase 2; Belongs to the aconitase/IPM isomerase family.
  
 
 0.988
Fbal_2487
COGs: COG0567 2-oxoglutarate dehydrogenase complex dehydrogenase (E1); InterPro IPR001017: IPR005475: IPR011603; KEGG: slo:Shew_1655 2-oxoglutarate dehydrogenase E1 component; PFAM: Transketolase central region; dehydrogenase E1 component; SPTR: A2V1H2 2-oxoglutarate dehydrogenase, E1 subunit; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 subunit; PFAM: Dehydrogenase E1 component; Transketolase, pyrimidine binding domain; TIGRFAM: 2-oxoglutarate dehydrogenase, E1 component.
   
 
 0.986
Fbal_2814
COGs: COG0473 Isocitrate/isopropylmalate dehydrogenase; InterPro IPR001804: IPR019818; KEGG: swp:swp_3606 isocitrate dehydrogenase; PFAM: isocitrate/isopropylmalate dehydrogenase; PRIAM: Isocitrate dehydrogenase (NAD(+)); SPTR: A2UVF1 Isocitrate/isopropylmalate dehydrogenase; PFAM: Isocitrate/isopropylmalate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NAD-dependent, mitochondrial type; isopropylmalate/isohomocitrate dehydrogenases; isocitrate dehydrogenase, NADP-dependent, prokaryotic type.
 
0.972
mdh
Malate dehydrogenase (NAD); Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 
 0.963
Fbal_1991
Isocitrate dehydrogenase, NADP-dependent; COGs: COG2838 Monomeric isocitrate dehydrogenase; InterPro IPR004436; KEGG: pin:Ping_0983 isocitrate dehydrogenase, NADP-dependent; PFAM: Isocitrate dehydrogenase NADP-dependent monomeric type; PRIAM: Isocitrate dehydrogenase (NADP(+)); SPTR: A0Y1L4 Isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent; PFAM: Monomeric isocitrate dehydrogenase; TIGRFAM: isocitrate dehydrogenase, NADP-dependent, monomeric type; Belongs to the monomeric-type IDH family.
    
 0.961
Fbal_1767
Fumarase; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
  
 0.944
Aconitase
Aconitase; COGs: COG1048 Aconitase A; InterPro IPR001030: IPR000573: IPR012708; KEGG: avn:Avin_23230 2-methylisocitrate dehydratase, Fe/S-dependent; PFAM: aconitate hydratase domain protein; SPTR: A3JGL7 Aconitate hydratase; TIGRFAM: 2-methylisocitrate dehydratase, Fe/S-dependent; PFAM: Aconitase C-terminal domain; Aconitase family (aconitate hydratase); TIGRFAM: 2-methylisocitrate dehydratase, Fe/S-dependent; aconitate hydratase 1.
 
 
 0.943
sucC
succinyl-CoA synthetase (ADP-forming) beta subunit; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.919
Fbal_3658
COGs: COG0372 Citrate synthase; InterPro IPR002020: IPR019810: IPR011278; KEGG: maq:Maqu_1665 methylcitrate synthase; PFAM: Citrate synthase; PRIAM: 2-methylcitrate synthase; SPTR: A0Y5Y9 Type II citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; PFAM: Citrate synthase; TIGRFAM: 2-methylcitrate synthase/citrate synthase II; Belongs to the citrate synthase family.
 
 
 0.916
aceK
(Isocitrate dehydrogenase (NADP(+))) kinase; Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
 
 
 0.909
Your Current Organism:
Ferrimonas balearica
NCBI taxonomy Id: 550540
Other names: F. balearica DSM 9799, Ferrimonas balearica DSM 9799, Ferrimonas balearica PAT, Ferrimonas balearica str. DSM 9799, Ferrimonas balearica strain DSM 9799
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