node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fbal_0002 | Fbal_1160 | Fbal_0002 | Fbal_1160 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | 0.977 |
Fbal_0002 | Fbal_2263 | Fbal_0002 | Fbal_2263 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | 0.916 |
Fbal_0002 | dnaE2 | Fbal_0002 | Fbal_2262 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.833 |
Fbal_0002 | ftsW | Fbal_0002 | Fbal_0345 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Cell division-specific peptidoglycan biosynthesis regulator FtsW; Peptidoglycan polymerase that is essential for cell division. Belongs to the SEDS family. FtsW subfamily. | 0.622 |
Fbal_0002 | lexA | Fbal_0002 | Fbal_0183 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.451 |
Fbal_0002 | mrdB | Fbal_0002 | Fbal_0818 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | Cell elongation-specific peptidoglycan biosynthesis regulator RodA; Peptidoglycan polymerase that is essential for cell wall elongation; Belongs to the SEDS family. MrdB/RodA subfamily. | 0.476 |
Fbal_0002 | polA | Fbal_0002 | Fbal_3739 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.996 |
Fbal_0002 | recA | Fbal_0002 | Fbal_0855 | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.930 |
Fbal_0184 | Fbal_2263 | Fbal_0184 | Fbal_2263 | KEGG: shm:Shewmr7_3863 hypothetical protein; SPTR: A2V2G6 Putative uncharacterized protein. | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | 0.834 |
Fbal_0184 | dnaE2 | Fbal_0184 | Fbal_2262 | KEGG: shm:Shewmr7_3863 hypothetical protein; SPTR: A2V2G6 Putative uncharacterized protein. | DNA polymerase III, alpha subunit; DNA polymerase involved in damage-induced mutagenesis and translesion synthesis (TLS). It is not the major replicative DNA polymerase. | 0.600 |
Fbal_0184 | lexA | Fbal_0184 | Fbal_0183 | KEGG: shm:Shewmr7_3863 hypothetical protein; SPTR: A2V2G6 Putative uncharacterized protein. | SOS-response transcriptional repressor, LexA; Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. | 0.963 |
Fbal_0184 | recA | Fbal_0184 | Fbal_0855 | KEGG: shm:Shewmr7_3863 hypothetical protein; SPTR: A2V2G6 Putative uncharacterized protein. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.710 |
Fbal_1160 | Fbal_0002 | Fbal_1160 | Fbal_0002 | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.977 |
Fbal_1160 | Fbal_2263 | Fbal_1160 | Fbal_2263 | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | 0.907 |
Fbal_1160 | polA | Fbal_1160 | Fbal_3739 | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family. | 0.944 |
Fbal_1160 | recA | Fbal_1160 | Fbal_0855 | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | recA protein; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family. | 0.848 |
Fbal_2263 | Fbal_0002 | Fbal_2263 | Fbal_0002 | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...] | 0.916 |
Fbal_2263 | Fbal_0184 | Fbal_2263 | Fbal_0184 | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | KEGG: shm:Shewmr7_3863 hypothetical protein; SPTR: A2V2G6 Putative uncharacterized protein. | 0.834 |
Fbal_2263 | Fbal_1160 | Fbal_2263 | Fbal_1160 | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | COGs: COG0417 DNA polymerase elongation subunit (family B); InterPro IPR017966: IPR006134: IPR006133: IPR006172: IPR 017964; KEGG: eta:ETA_07310 DNA polymerase II; PFAM: DNA polymerase B region; DNA polymerase B exonuclease; PRIAM: DNA-directed DNA polymerase; SMART: DNA-directed DNA polymerase B; SPTR: A3KT91 DNA polymerase; PFAM: DNA polymerase family B; DNA polymerase family B, exonuclease domain. | 0.907 |
Fbal_2263 | Fbal_2264 | Fbal_2263 | Fbal_2264 | KEGG: maq:Maqu_0974 hypothetical protein; SPTR: A3JJR9 DinP DNA polymerase-like protein. | Conserved hypothetical protein; Component of the SOS system and an inhibitor of cell division. Accumulation of SulA causes rapid cessation of cell division and the appearance of long, non-septate filaments. In the presence of GTP, binds a polymerization-competent form of FtsZ in a 1:1 ratio, thus inhibiting FtsZ polymerization and therefore preventing it from participating in the assembly of the Z ring. This mechanism prevents the premature segregation of damaged DNA to daughter cells during cell division. | 0.995 |