| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Fbal_0712 | Fbal_3401 | Fbal_0712 | Fbal_3401 | Putative adenylate/guanylate cyclase; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: slo:Shew_1036 putative adenylate/guanylate cyclase; SPTR: A2V2C9 Putative adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain. | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | 0.700 |
| Fbal_0712 | Fbal_3692 | Fbal_0712 | Fbal_3692 | Putative adenylate/guanylate cyclase; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: slo:Shew_1036 putative adenylate/guanylate cyclase; SPTR: A2V2C9 Putative adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain. | COGs: COG3072 Adenylate cyclase; InterPro IPR000274; KEGG: shw:Sputw3181_3725 adenylate cyclase; PFAM: adenylate cyclase class-I; PRIAM: Adenylate cyclase; SPTR: A2UYN9 Adenylate cyclase, class-I; PFAM: Adenylate cyclase, class-I. | 0.919 |
| Fbal_0712 | cpdA | Fbal_0712 | Fbal_3284 | Putative adenylate/guanylate cyclase; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: slo:Shew_1036 putative adenylate/guanylate cyclase; SPTR: A2V2C9 Putative adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain. | Calcineurin phosphoesterase domain protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.919 |
| Fbal_0806 | Fbal_3401 | Fbal_0806 | Fbal_3401 | Doubled CXXCH domain protein; InterPro IPR011717: IPR001440: IPR010177: IPR013105: IPR 019734: IPR013026: IPR011031; KEGG: ppw:PputW619_1988 TPR repeat-containing protein; PFAM: doubled CXXCH domain protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; SPTR: A0YGC8 TPR domain protein; PFAM: Doubled CXXCH motif (Paired_CXXCH_1); Tetratricopeptide repeat; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; doubled CXXCH domain. | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | 0.595 |
| Fbal_0806 | rpoA | Fbal_0806 | Fbal_0294 | Doubled CXXCH domain protein; InterPro IPR011717: IPR001440: IPR010177: IPR013105: IPR 019734: IPR013026: IPR011031; KEGG: ppw:PputW619_1988 TPR repeat-containing protein; PFAM: doubled CXXCH domain protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; SPTR: A0YGC8 TPR domain protein; PFAM: Doubled CXXCH motif (Paired_CXXCH_1); Tetratricopeptide repeat; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; doubled CXXCH domain. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.813 |
| Fbal_0806 | rpoB | Fbal_0806 | Fbal_0251 | Doubled CXXCH domain protein; InterPro IPR011717: IPR001440: IPR010177: IPR013105: IPR 019734: IPR013026: IPR011031; KEGG: ppw:PputW619_1988 TPR repeat-containing protein; PFAM: doubled CXXCH domain protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; SPTR: A0YGC8 TPR domain protein; PFAM: Doubled CXXCH motif (Paired_CXXCH_1); Tetratricopeptide repeat; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; doubled CXXCH domain. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.800 |
| Fbal_0806 | rpoZ | Fbal_0806 | Fbal_0111 | Doubled CXXCH domain protein; InterPro IPR011717: IPR001440: IPR010177: IPR013105: IPR 019734: IPR013026: IPR011031; KEGG: ppw:PputW619_1988 TPR repeat-containing protein; PFAM: doubled CXXCH domain protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; SPTR: A0YGC8 TPR domain protein; PFAM: Doubled CXXCH motif (Paired_CXXCH_1); Tetratricopeptide repeat; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; doubled CXXCH domain. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.780 |
| Fbal_3386 | Fbal_3401 | Fbal_3386 | Fbal_3401 | COGs: COG3112 conserved hypothetical protein; InterPro IPR008249; KEGG: saz:Sama_0645 hypothetical protein; PFAM: conserved hypothetical protein; SPTR: A1S397 UPF0231 protein Sama_0645; PFAM: Uncharacterised protein family (UPF0231); Belongs to the UPF0231 family. | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | 0.679 |
| Fbal_3401 | Fbal_0712 | Fbal_3401 | Fbal_0712 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | Putative adenylate/guanylate cyclase; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: slo:Shew_1036 putative adenylate/guanylate cyclase; SPTR: A2V2C9 Putative adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain. | 0.700 |
| Fbal_3401 | Fbal_0806 | Fbal_3401 | Fbal_0806 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | Doubled CXXCH domain protein; InterPro IPR011717: IPR001440: IPR010177: IPR013105: IPR 019734: IPR013026: IPR011031; KEGG: ppw:PputW619_1988 TPR repeat-containing protein; PFAM: doubled CXXCH domain protein; TPR repeat-containing protein; Tetratricopeptide TPR_4; Tetratricopeptide TPR_2 repeat protein; SMART: Tetratricopeptide repeat; SPTR: A0YGC8 TPR domain protein; PFAM: Doubled CXXCH motif (Paired_CXXCH_1); Tetratricopeptide repeat; TIGRFAM: glutamate--cysteine ligase/gamma-glutamylcysteine synthetase, Streptococcus agalactiae type; doubled CXXCH domain. | 0.595 |
| Fbal_3401 | Fbal_3386 | Fbal_3401 | Fbal_3386 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | COGs: COG3112 conserved hypothetical protein; InterPro IPR008249; KEGG: saz:Sama_0645 hypothetical protein; PFAM: conserved hypothetical protein; SPTR: A1S397 UPF0231 protein Sama_0645; PFAM: Uncharacterised protein family (UPF0231); Belongs to the UPF0231 family. | 0.679 |
| Fbal_3401 | Fbal_3692 | Fbal_3401 | Fbal_3692 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | COGs: COG3072 Adenylate cyclase; InterPro IPR000274; KEGG: shw:Sputw3181_3725 adenylate cyclase; PFAM: adenylate cyclase class-I; PRIAM: Adenylate cyclase; SPTR: A2UYN9 Adenylate cyclase, class-I; PFAM: Adenylate cyclase, class-I. | 0.723 |
| Fbal_3401 | cpdA | Fbal_3401 | Fbal_3284 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | Calcineurin phosphoesterase domain protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes. | 0.688 |
| Fbal_3401 | rpoA | Fbal_3401 | Fbal_0294 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.797 |
| Fbal_3401 | rpoB | Fbal_3401 | Fbal_0251 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.803 |
| Fbal_3401 | rpoC | Fbal_3401 | Fbal_0252 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | DNA-directed RNA polymerase subunit beta; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. | 0.796 |
| Fbal_3401 | rpoD | Fbal_3401 | Fbal_3272 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | RNA polymerase, sigma 70 subunit, RpoD; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. | 0.832 |
| Fbal_3401 | rpoZ | Fbal_3401 | Fbal_0111 | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | DNA-directed RNA polymerase subunit omega; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.778 |
| Fbal_3692 | Fbal_0712 | Fbal_3692 | Fbal_0712 | COGs: COG3072 Adenylate cyclase; InterPro IPR000274; KEGG: shw:Sputw3181_3725 adenylate cyclase; PFAM: adenylate cyclase class-I; PRIAM: Adenylate cyclase; SPTR: A2UYN9 Adenylate cyclase, class-I; PFAM: Adenylate cyclase, class-I. | Putative adenylate/guanylate cyclase; COGs: COG2114 Adenylate cyclase family 3 (some protein contain HAMP domain); InterPro IPR001054; KEGG: slo:Shew_1036 putative adenylate/guanylate cyclase; SPTR: A2V2C9 Putative adenylate/guanylate cyclase; PFAM: Adenylate and Guanylate cyclase catalytic domain. | 0.919 |
| Fbal_3692 | Fbal_3401 | Fbal_3692 | Fbal_3401 | COGs: COG3072 Adenylate cyclase; InterPro IPR000274; KEGG: shw:Sputw3181_3725 adenylate cyclase; PFAM: adenylate cyclase class-I; PRIAM: Adenylate cyclase; SPTR: A2UYN9 Adenylate cyclase, class-I; PFAM: Adenylate cyclase, class-I. | Transcriptional regulator, Crp/Fnr family; COGs: COG0664 cAMP-binding protein - catabolite gene activator and regulatory subunit of cAMP-dependent protein kinase; InterPro IPR001808: IPR000595: IPR018488: IPR018335: IPR 012318; KEGG: swd:Swoo_0662 cAMP-regulatory protein; PFAM: cyclic nucleotide-binding; regulatory protein Crp; SMART: cyclic nucleotide-binding; regulatory protein Crp; SPTR: A2UWN4 Transcriptional regulator, Crp/Fnr family; PFAM: Bacterial regulatory proteins, crp family; Cyclic nucleotide-binding domain. | 0.723 |