node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Aazo_0317 | hisA | Aazo_0317 | Aazo_2744 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | 0.827 |
Aazo_0317 | hisB | Aazo_0317 | Aazo_1063 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | KEGG: ana:all4390 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.919 |
Aazo_0317 | hisD | Aazo_0317 | Aazo_1020 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.938 |
Aazo_0317 | hisF | Aazo_0317 | Aazo_1893 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.841 |
Aazo_0317 | hisG | Aazo_0317 | Aazo_2454 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.827 |
Aazo_0317 | hisH | Aazo_0317 | Aazo_2143 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.904 |
Aazo_0317 | hisI | Aazo_0317 | Aazo_2676 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | phosphoribosyl-ATP diphosphatase; KEGG: npu:Npun_F4098 phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.994 |
Aazo_0317 | hisZ | Aazo_0317 | Aazo_0886 | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.741 |
Aazo_1414 | hisI | Aazo_1414 | Aazo_2676 | PFAM: CMP/dCMP deaminase zinc-binding; KEGG: npu:Npun_F6608 CMP/dCMP deaminase, zinc-binding. | phosphoribosyl-ATP diphosphatase; KEGG: npu:Npun_F4098 phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.908 |
hisA | Aazo_0317 | Aazo_2744 | Aazo_0317 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | 0.827 |
hisA | hisB | Aazo_2744 | Aazo_1063 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | KEGG: ana:all4390 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | 0.984 |
hisA | hisC | Aazo_2744 | Aazo_2341 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | PFAM: aminotransferase class I and II; KEGG: npu:Npun_R0899 aminotransferase, class I and II; Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily. | 0.837 |
hisA | hisD | Aazo_2744 | Aazo_1020 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.985 |
hisA | hisF | Aazo_2744 | Aazo_1893 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | Imidazoleglycerol phosphate synthase, cyclase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.998 |
hisA | hisG | Aazo_2744 | Aazo_2454 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Short subfamily. | 0.983 |
hisA | hisH | Aazo_2744 | Aazo_2143 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | Imidazole glycerol phosphate synthase, glutamine amidotransferase subunit; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisI | Aazo_2744 | Aazo_2676 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | phosphoribosyl-ATP diphosphatase; KEGG: npu:Npun_F4098 phosphoribosyl-AMP cyclohydrolase; TIGRFAM: phosphoribosyl-ATP diphosphatase; PFAM: phosphoribosyl-AMP cyclohydrolase; phosphoribosyl-ATP pyrophosphohydrolase; In the N-terminal section; belongs to the PRA-CH family. | 0.999 |
hisA | hisZ | Aazo_2744 | Aazo_0886 | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | histidyl-tRNA synthetase 2; Required for the first step of histidine biosynthesis. May allow the feedback regulation of ATP phosphoribosyltransferase activity by histidine. | 0.917 |
hisB | Aazo_0317 | Aazo_1063 | Aazo_0317 | KEGG: ana:all4390 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | TIGRFAM: L-threonine-O-3-phosphate decarboxylase; KEGG: npu:Npun_F5011 putative L-threonine-O-3-phosphate decarboxylase; PFAM: aminotransferase class I and II. | 0.919 |
hisB | hisA | Aazo_1063 | Aazo_2744 | KEGG: ana:all4390 imidazoleglycerol-phosphate dehydratase; PFAM: imidazoleglycerol-phosphate dehydratase. | TIGRFAM: phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase; KEGG: ava:Ava_3372 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase; PFAM: histidine biosynthesis protein. | 0.984 |