STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Aazo_5011PFAM: thymidylate synthase; KEGG: cyp:PCC8801_1245 thymidylate synthase. (497 aa)    
Predicted Functional Partners:
Aazo_1890
Dihydrofolate reductase region; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis.
  
 
 0.986
Aazo_5014
PFAM: CMP/dCMP deaminase zinc-binding; KEGG: cyc:PCC7424_0712 CMP/dCMP deaminase zinc-binding.
 
 
 0.951
tmk
Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family.
  
 
 0.941
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.935
glyA
Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 
 0.934
gcvT
Glycine cleavage system T protein; The glycine cleavage system catalyzes the degradation of glycine.
    
 0.930
Aazo_4669
PFAM: methylenetetrahydrofolate reductase; KEGG: npu:Npun_R5069 methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family.
     
 0.927
surE
Stationary-phase survival protein SurE; Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates; Belongs to the SurE nucleotidase family.
   
 
 0.917
Aazo_0325
TIGRFAM: FolC bifunctional protein; KEGG: ana:alr1026 folylpolyglutamate synthase; PFAM: cytoplasmic peptidoglycan synthetase domain protein; Mur ligase middle domain protein.
     
 0.855
Aazo_2082
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.775
Your Current Organism:
Nostoc azollae
NCBI taxonomy Id: 551115
Other names: '. azollae' 0708, 'Nostoc azollae' 0708, Anabaena azollae 0708
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