STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. (322 aa)    
Predicted Functional Partners:
Aazo_4544
Porphobilinogen synthase; KEGG: ava:Ava_3297 delta-aminolevulinic acid dehydratase; PFAM: delta-aminolevulinic acid dehydratase; Belongs to the ALAD family.
 
 0.995
Aazo_2092
PFAM: Uroporphyrinogen III synthase HEM4; KEGG: npu:Npun_R1629 uroporphyrinogen III synthase HEM4.
 
 0.992
Aazo_3492
KEGG: npu:Npun_R1873 uroporphyrin-III C-methyltransferase; TIGRFAM: uroporphyrin-III C-methyltransferase; PFAM: Uroporphyrin-III C/tetrapyrrole (Corrin/Porphyrin) methyltransferase; Belongs to the precorrin methyltransferase family.
  
 0.987
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.984
hemE
Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.
 
 0.983
hemL
Glutamate-1-semialdehyde-2,1-aminomutase; KEGG: ava:Ava_4920 glutamate-1-semialdehyde aminotransferase; TIGRFAM: glutamate-1-semialdehyde-2,1-aminomutase; PFAM: aminotransferase class-III; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.
 
  
 0.929
pgl
6-phosphogluconolactonase; Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate.
 
    
 0.738
glgA
Glycogen/starch synthase, ADP-glucose type; Synthesizes alpha-1,4-glucan chains using ADP-glucose.
       0.704
Aazo_5130
Hypothetical protein; KEGG: similar to GJ14616.
       0.686
hemH
Ferrochelatase; Catalyzes the ferrous insertion into protoporphyrin IX. Belongs to the ferrochelatase family.
 
  
 0.598
Your Current Organism:
Nostoc azollae
NCBI taxonomy Id: 551115
Other names: '. azollae' 0708, 'Nostoc azollae' 0708, Anabaena azollae 0708
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