node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SIS62061.1 | SIS62099.1 | SAMN05421796_101635 | SAMN05421796_101638 | Homoserine dehydrogenase. | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 0.971 |
SIS62061.1 | SIS62132.1 | SAMN05421796_101635 | SAMN05421796_101640 | Homoserine dehydrogenase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.968 |
SIS62061.1 | SIS62159.1 | SAMN05421796_101635 | SAMN05421796_101642 | Homoserine dehydrogenase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.956 |
SIS62061.1 | SIS69557.1 | SAMN05421796_101635 | SAMN05421796_10272 | Homoserine dehydrogenase. | Cystathionine gamma-lyase. | 0.973 |
SIS62061.1 | SIT01701.1 | SAMN05421796_101635 | SAMN05421796_10965 | Homoserine dehydrogenase. | Methionine-gamma-lyase. | 0.870 |
SIS62061.1 | ahcY | SAMN05421796_101635 | SAMN05421796_104241 | Homoserine dehydrogenase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.916 |
SIS62061.1 | glyA | SAMN05421796_101635 | SAMN05421796_104269 | Homoserine dehydrogenase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.847 |
SIS62061.1 | metK | SAMN05421796_101635 | SAMN05421796_11119 | Homoserine dehydrogenase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.733 |
SIS62061.1 | metZ | SAMN05421796_101635 | SAMN05421796_101636 | Homoserine dehydrogenase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.986 |
SIS62099.1 | SIS62061.1 | SAMN05421796_101638 | SAMN05421796_101635 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Homoserine dehydrogenase. | 0.971 |
SIS62099.1 | SIS62132.1 | SAMN05421796_101638 | SAMN05421796_101640 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | 0.999 |
SIS62099.1 | SIS62159.1 | SAMN05421796_101638 | SAMN05421796_101642 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | 5,10-methylenetetrahydrofolate reductase (NAD(P)); Belongs to the methylenetetrahydrofolate reductase family. | 0.996 |
SIS62099.1 | SIS69557.1 | SAMN05421796_101638 | SAMN05421796_10272 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Cystathionine gamma-lyase. | 0.946 |
SIS62099.1 | SIT01701.1 | SAMN05421796_101638 | SAMN05421796_10965 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine-gamma-lyase. | 0.946 |
SIS62099.1 | ahcY | SAMN05421796_101638 | SAMN05421796_104241 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.932 |
SIS62099.1 | gcvT | SAMN05421796_101638 | SAMN05421796_102254 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.925 |
SIS62099.1 | glyA | SAMN05421796_101638 | SAMN05421796_104269 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.927 |
SIS62099.1 | metK | SAMN05421796_101638 | SAMN05421796_11119 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | Methionine adenosyltransferase; Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.931 |
SIS62099.1 | metZ | SAMN05421796_101638 | SAMN05421796_101636 | 5-methyltetrahydrofolate--homocysteine methyltransferase. | O-succinylhomoserine sulfhydrylase; Catalyzes the formation of L-homocysteine from O-succinyl-L- homoserine (OSHS) and hydrogen sulfide. | 0.979 |
SIS62132.1 | SIS62061.1 | SAMN05421796_101640 | SAMN05421796_101635 | Methionine synthase (B12-dependent); Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate. | Homoserine dehydrogenase. | 0.968 |