node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SHM30859.1 | SHM76212.1 | SAMN05192549_101253 | SAMN05192549_102437 | Acetolactate synthase, small subunit. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.978 |
SHM30859.1 | SHM88060.1 | SAMN05192549_101253 | SAMN05192549_103100 | Acetolactate synthase, small subunit. | Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. | 0.868 |
SHM30859.1 | SHN30761.1 | SAMN05192549_101253 | SAMN05192549_10798 | Acetolactate synthase, small subunit. | Branched-chain amino acid aminotransferase. | 0.859 |
SHM30859.1 | ilvC | SAMN05192549_101253 | SAMN05192549_101252 | Acetolactate synthase, small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
SHM30859.1 | ilvD | SAMN05192549_101253 | SAMN05192549_111111 | Acetolactate synthase, small subunit. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.971 |
SHM30859.1 | leuA-2 | SAMN05192549_101253 | SAMN05192549_107274 | Acetolactate synthase, small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.962 |
SHM30859.1 | leuB | SAMN05192549_101253 | SAMN05192549_101516 | Acetolactate synthase, small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. | 0.986 |
SHM30859.1 | leuC | SAMN05192549_101253 | SAMN05192549_101519 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.964 |
SHM30859.1 | leuD | SAMN05192549_101253 | SAMN05192549_101517 | Acetolactate synthase, small subunit. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.981 |
SHM76212.1 | SHM30859.1 | SAMN05192549_102437 | SAMN05192549_101253 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Acetolactate synthase, small subunit. | 0.978 |
SHM76212.1 | SHM88060.1 | SAMN05192549_102437 | SAMN05192549_103100 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. | 0.535 |
SHM76212.1 | ilvC | SAMN05192549_102437 | SAMN05192549_101252 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.952 |
SHM76212.1 | ilvD | SAMN05192549_102437 | SAMN05192549_111111 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | Dihydroxyacid dehydratase; Belongs to the IlvD/Edd family. | 0.922 |
SHM76212.1 | leuA-2 | SAMN05192549_102437 | SAMN05192549_107274 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.935 |
SHM76212.1 | leuC | SAMN05192549_102437 | SAMN05192549_101519 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.986 |
SHM76212.1 | leuD | SAMN05192549_102437 | SAMN05192549_101517 | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.981 |
SHM88060.1 | SHM30859.1 | SAMN05192549_103100 | SAMN05192549_101253 | Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. | Acetolactate synthase, small subunit. | 0.868 |
SHM88060.1 | SHM76212.1 | SAMN05192549_103100 | SAMN05192549_102437 | Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. | Tartrate dehydrogenase/decarboxylase / D-malate dehydrogenase. | 0.535 |
SHM88060.1 | SHN30761.1 | SAMN05192549_103100 | SAMN05192549_10798 | Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. | Branched-chain amino acid aminotransferase. | 0.664 |
SHM88060.1 | ilvC | SAMN05192549_103100 | SAMN05192549_101252 | Para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.842 |