| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| SDI89257.1 | SDI89297.1 | SAMN05192550_1083 | SAMN05192550_1084 | Periplasmic chaperone for outer membrane proteins Skp. | Periplasmic chaperone for outer membrane proteins Skp. | 0.890 |
| SDI89257.1 | murI | SAMN05192550_1083 | SAMN05192550_1082 | Periplasmic chaperone for outer membrane proteins Skp. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.618 |
| SDI89257.1 | uppS | SAMN05192550_1083 | SAMN05192550_1086 | Periplasmic chaperone for outer membrane proteins Skp. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.696 |
| SDI89297.1 | SDI89257.1 | SAMN05192550_1084 | SAMN05192550_1083 | Periplasmic chaperone for outer membrane proteins Skp. | Periplasmic chaperone for outer membrane proteins Skp. | 0.890 |
| SDI89297.1 | murI | SAMN05192550_1084 | SAMN05192550_1082 | Periplasmic chaperone for outer membrane proteins Skp. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.576 |
| SDI89297.1 | uppS | SAMN05192550_1084 | SAMN05192550_1086 | Periplasmic chaperone for outer membrane proteins Skp. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.746 |
| SDK07201.1 | gltA | SAMN05192550_3277 | SAMN05192550_1632 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate synthase (NADH) large subunit. | 0.474 |
| SDK07201.1 | guaB | SAMN05192550_3277 | SAMN05192550_1674 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.918 |
| SDK07201.1 | murD | SAMN05192550_3277 | SAMN05192550_1209 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.430 |
| SDK07201.1 | murI | SAMN05192550_3277 | SAMN05192550_1082 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.924 |
| SDK07201.1 | uppS | SAMN05192550_3277 | SAMN05192550_1086 | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Undecaprenyl diphosphate synthase; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids. | 0.576 |
| gdhA | gltA | SAMN05192550_0755 | SAMN05192550_1632 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate synthase (NADH) large subunit. | 0.999 |
| gdhA | murI | SAMN05192550_0755 | SAMN05192550_1082 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.726 |
| gdhA | purL | SAMN05192550_0755 | SAMN05192550_1963 | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.703 |
| gltA | SDK07201.1 | SAMN05192550_1632 | SAMN05192550_3277 | Glutamate synthase (NADH) large subunit. | XTP/dITP diphosphohydrolase; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.474 |
| gltA | gdhA | SAMN05192550_1632 | SAMN05192550_0755 | Glutamate synthase (NADH) large subunit. | Glutamate dehydrogenase (NADP+); Belongs to the Glu/Leu/Phe/Val dehydrogenases family. | 0.999 |
| gltA | guaB | SAMN05192550_1632 | SAMN05192550_1674 | Glutamate synthase (NADH) large subunit. | IMP dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.901 |
| gltA | murD | SAMN05192550_1632 | SAMN05192550_1209 | Glutamate synthase (NADH) large subunit. | UDP-N-acetylmuramoylalanine--D-glutamate ligase; Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA). Belongs to the MurCDEF family. | 0.488 |
| gltA | murI | SAMN05192550_1632 | SAMN05192550_1082 | Glutamate synthase (NADH) large subunit. | Glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.568 |
| gltA | purL | SAMN05192550_1632 | SAMN05192550_1963 | Glutamate synthase (NADH) large subunit. | Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. | 0.872 |