| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Acs | Pyk | SAMN05192573_108229 | SAMN05192573_115136 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.415 |
| Acs | SDG30916.1 | SAMN05192573_108229 | SAMN05192573_10348 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.912 |
| Acs | SDG86721.1 | SAMN05192573_108229 | SAMN05192573_105146 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.839 |
| Acs | SDH01236.1 | SAMN05192573_108229 | SAMN05192573_10683 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.940 |
| Acs | SDI04592.1 | SAMN05192573_108229 | SAMN05192573_115117 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde dehydrogenase (NAD+). | 0.940 |
| Acs | SDI34994.1 | SAMN05192573_108229 | SAMN05192573_11953 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Allosteric NADP-dependent malic enzyme. | 0.593 |
| Acs | ackA | SAMN05192573_108229 | SAMN05192573_10330 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Acetate kinase; Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family. | 0.927 |
| Acs | pdhA | SAMN05192573_108229 | SAMN05192573_105180 | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.836 |
| Pyk | Acs | SAMN05192573_115136 | SAMN05192573_108229 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.415 |
| Pyk | SDG30916.1 | SAMN05192573_115136 | SAMN05192573_10348 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | 0.918 |
| Pyk | SDG86721.1 | SAMN05192573_115136 | SAMN05192573_105146 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.917 |
| Pyk | SDH39422.1 | SAMN05192573_115136 | SAMN05192573_109117 | Pyruvate kinase; Belongs to the pyruvate kinase family. | D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.947 |
| Pyk | SDI34994.1 | SAMN05192573_115136 | SAMN05192573_11953 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Allosteric NADP-dependent malic enzyme. | 0.968 |
| Pyk | ilvN | SAMN05192573_115136 | SAMN05192573_117144 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Acetolactate synthase, small subunit. | 0.802 |
| Pyk | pdhA | SAMN05192573_115136 | SAMN05192573_105180 | Pyruvate kinase; Belongs to the pyruvate kinase family. | Pyruvate dehydrogenase E1 component alpha subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). | 0.917 |
| SDG30916.1 | Acs | SAMN05192573_10348 | SAMN05192573_108229 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Acetyl-coenzyme A synthetase; Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.912 |
| SDG30916.1 | Pyk | SAMN05192573_10348 | SAMN05192573_115136 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Pyruvate kinase; Belongs to the pyruvate kinase family. | 0.918 |
| SDG30916.1 | SDG86721.1 | SAMN05192573_10348 | SAMN05192573_105146 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Pyruvate dehydrogenase E1 component beta subunit; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. | 0.908 |
| SDG30916.1 | SDH01236.1 | SAMN05192573_10348 | SAMN05192573_10683 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | Aldehyde dehydrogenase; Belongs to the aldehyde dehydrogenase family. | 0.909 |
| SDG30916.1 | SDH39422.1 | SAMN05192573_10348 | SAMN05192573_109117 | Pyruvate dehydrogenase (quinone); Belongs to the TPP enzyme family. | D-lactate dehydrogenase; Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. | 0.922 |