| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HA50_02550 | HA50_03745 | HA50_02550 | HA50_03745 | Enterochelin esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.487 |
| HA50_03565 | HA50_03745 | HA50_03565 | HA50_03745 | Regulatory signaling modulator protein AmpE; Involved in regulation of beta-lactamase; putative signaling protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.539 |
| HA50_03565 | HA50_14520 | HA50_03565 | HA50_14520 | Regulatory signaling modulator protein AmpE; Involved in regulation of beta-lactamase; putative signaling protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Stationary phase inducible protein CsiE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.555 |
| HA50_03745 | HA50_02550 | HA50_03745 | HA50_02550 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Enterochelin esterase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.487 |
| HA50_03745 | HA50_03565 | HA50_03745 | HA50_03565 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Regulatory signaling modulator protein AmpE; Involved in regulation of beta-lactamase; putative signaling protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.539 |
| HA50_03745 | HA50_03750 | HA50_03745 | HA50_03750 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.593 |
| HA50_03745 | HA50_03755 | HA50_03745 | HA50_03755 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.448 |
| HA50_03745 | HA50_14520 | HA50_03745 | HA50_14520 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Stationary phase inducible protein CsiE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.473 |
| HA50_03745 | bioD-2 | HA50_03745 | HA50_10020 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Dethiobiotin synthase; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.494 |
| HA50_03745 | dksA | HA50_03745 | HA50_03735 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 0.446 |
| HA50_03745 | galK | HA50_03745 | HA50_05815 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. | 0.542 |
| HA50_03745 | galK-2 | HA50_03745 | HA50_22480 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Galactokinase; Catalyzes the transfer of the gamma-phosphate of ATP to D- galactose to form alpha-D-galactose-1-phosphate (Gal-1-P). Belongs to the GHMP kinase family. GalK subfamily. | 0.542 |
| HA50_03745 | sfsA | HA50_03745 | HA50_03740 | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | Sugar fermentation stimulation protein SfsA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.806 |
| HA50_03750 | HA50_03745 | HA50_03750 | HA50_03745 | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.593 |
| HA50_03750 | HA50_03755 | HA50_03750 | HA50_03755 | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 0.558 |
| HA50_03750 | sfsA | HA50_03750 | HA50_03740 | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | Sugar fermentation stimulation protein SfsA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.596 |
| HA50_03755 | HA50_03745 | HA50_03755 | HA50_03745 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | 2'-5' RNA ligase; Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'- phosphomonoester; Belongs to the 2H phosphoesterase superfamily. ThpR family. | 0.448 |
| HA50_03755 | HA50_03750 | HA50_03755 | HA50_03750 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | ATP-dependent helicase HrpB; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.558 |
| HA50_03755 | dksA | HA50_03755 | HA50_03735 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | RNA polymerase-binding protein DksA; Transcription factor that acts by binding directly to the RNA polymerase (RNAP). Required for negative regulation of rRNA expression and positive regulation of several amino acid biosynthesis promoters. Also required for regulation of fis expression. | 0.435 |
| HA50_03755 | sfsA | HA50_03755 | HA50_03740 | Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits). | Sugar fermentation stimulation protein SfsA; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the SfsA family. | 0.472 |