| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| HA50_02335 | HA50_16120 | HA50_02335 | HA50_16120 | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.709 |
| HA50_02335 | apaH | HA50_02335 | HA50_03310 | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.672 |
| HA50_02335 | cca | HA50_02335 | HA50_17510 | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | 2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. | 0.737 |
| HA50_02335 | ftsB | HA50_02335 | HA50_15310 | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.764 |
| HA50_02335 | ftsQ | HA50_02335 | HA50_03485 | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.690 |
| HA50_02335 | tuf | HA50_02335 | HA50_00810 | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | Elongation factor Tu; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.664 |
| HA50_15815 | HA50_16120 | HA50_15815 | HA50_16120 | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.690 |
| HA50_15815 | apaH | HA50_15815 | HA50_03310 | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | Bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.460 |
| HA50_15815 | erpA | HA50_15815 | HA50_03785 | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | Iron-sulfur cluster insertion protein ErpA; Required for insertion of 4Fe-4S clusters for at least IspG. | 0.686 |
| HA50_15815 | ftsB | HA50_15815 | HA50_15310 | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | Cell division protein FtsB; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. | 0.524 |
| HA50_15815 | ftsQ | HA50_15815 | HA50_03485 | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | Cell division protein FtsQ; Essential cell division protein. May link together the upstream cell division proteins, which are predominantly cytoplasmic, with the downstream cell division proteins, which are predominantly periplasmic. May control correct divisome assembly. | 0.612 |
| HA50_15815 | tuf | HA50_15815 | HA50_00810 | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | Elongation factor Tu; Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation; Belongs to the SecE/SEC61-gamma family. | 0.642 |
| HA50_16115 | HA50_16120 | HA50_16115 | HA50_16120 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 0.827 |
| HA50_16115 | HA50_16125 | HA50_16115 | HA50_16125 | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | Murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | 0.688 |
| HA50_16120 | HA50_02335 | HA50_16120 | HA50_02335 | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | ClpXP protease specificity-enhancing factor; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.709 |
| HA50_16120 | HA50_15815 | HA50_16120 | HA50_15815 | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | tRNA-modifying protein YgfZ; Folate-binding protein involved in regulating the level of ATP-DnaA and in the modification of some tRNAs. It is probably a key factor in regulatory networks that act via tRNA modification, such as initiation of chromosomal replication; Belongs to the tRNA-modifying YgfZ family. | 0.690 |
| HA50_16120 | HA50_16115 | HA50_16120 | HA50_16115 | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | A/G-specific adenine glycosylase; Adenine glycosylase active on G-A mispairs. | 0.827 |
| HA50_16120 | HA50_16125 | HA50_16120 | HA50_16125 | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Murein transglycosylase C; Murein-degrading enzyme. May play a role in recycling of muropeptides during cell elongation and/or cell division. | 0.719 |
| HA50_16120 | apaH | HA50_16120 | HA50_03310 | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | Bis(5'-nucleosyl)-tetraphosphatase (symmetrical); Hydrolyzes diadenosine 5',5'''-P1,P4-tetraphosphate to yield ADP; Belongs to the Ap4A hydrolase family. | 0.645 |
| HA50_16120 | cca | HA50_16120 | HA50_17510 | Oxidative damage protection protein; Could be a mediator in iron transactions between iron acquisition and iron-requiring processes, such as synthesis and/or repair of Fe-S clusters in biosynthetic enzymes; Belongs to the Fe(2+)-trafficking protein family. | 2',3'-cyclic phosphodiesterase; Catalyzes the addition and repair of the essential 3'- terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate. Also shows phosphatase, 2'-nucleotidase and 2',3'-cyclic phosphodiesterase activities. These phosphohydrolase activities are probably involved in the repair of the tRNA 3'-CCA terminus degraded by intracellular RNases. | 0.630 |