node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
HA50_02350 | HA50_04785 | HA50_02350 | HA50_04785 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Ammonium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.852 |
HA50_02350 | HA50_20275 | HA50_02350 | HA50_20275 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.989 |
HA50_02350 | glnD | HA50_02350 | HA50_03835 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | [protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.679 |
HA50_02350 | glnE | HA50_02350 | HA50_17495 | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.888 |
HA50_04785 | HA50_02350 | HA50_04785 | HA50_02350 | Ammonium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.852 |
HA50_04785 | HA50_20275 | HA50_04785 | HA50_20275 | Ammonium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.400 |
HA50_04785 | glnD | HA50_04785 | HA50_03835 | Ammonium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | [protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen metabolism. | 0.603 |
HA50_04785 | glnE | HA50_04785 | HA50_17495 | Ammonium transporter; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.467 |
HA50_06050 | glnE | HA50_06050 | HA50_17495 | Chemotaxis protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.445 |
HA50_06665 | HA50_18405 | HA50_06665 | HA50_18405 | DNA internalization-related competence protein ComEC/Rec2; Derived by automated computational analysis using gene prediction method: Protein Homology. | TIGR02099 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.482 |
HA50_06665 | glnE | HA50_06665 | HA50_17495 | DNA internalization-related competence protein ComEC/Rec2; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.477 |
HA50_17500 | HA50_17505 | HA50_17500 | HA50_17505 | Inorganic triphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.551 |
HA50_17500 | glnE | HA50_17500 | HA50_17495 | Inorganic triphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.716 |
HA50_17500 | hldE | HA50_17500 | HA50_17490 | Inorganic triphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.591 |
HA50_17505 | HA50_17500 | HA50_17505 | HA50_17500 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Inorganic triphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.551 |
HA50_17505 | glnE | HA50_17505 | HA50_17495 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.594 |
HA50_17505 | hldE | HA50_17505 | HA50_17490 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional heptose 7-phosphate kinase/heptose 1-phosphate adenyltransferase; Catalyzes the ADP transfer from ATP to D-glycero-beta-D- manno-heptose 1-phosphate, yielding ADP-D-glycero-beta-D-manno-heptose. In the N-terminal section; belongs to the carbohydrate kinase PfkB family. | 0.521 |
HA50_18405 | HA50_06665 | HA50_18405 | HA50_06665 | TIGR02099 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | DNA internalization-related competence protein ComEC/Rec2; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.482 |
HA50_18405 | glnE | HA50_18405 | HA50_17495 | TIGR02099 family protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Bifunctional glutamine synthetase adenylyltransferase/deadenyltransferase; Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of [...] | 0.448 |
HA50_20275 | HA50_02350 | HA50_20275 | HA50_02350 | Type I glutamate--ammonia ligase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Glutamate synthase large subunit; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.989 |