STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pfpDiphosphate--fructose-6-phosphate 1-phosphotransferase; Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP- PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions. (547 aa)    
Predicted Functional Partners:
pgi
Glucose-6-phosphate isomerase; Identified by match to protein family HMM PF00342; Belongs to the GPI family.
  
 0.963
fba
Fructose-1,6-bisphosphate aldolase, class II; Identified by match to protein family HMM PF01116; match to protein family HMM TIGR00167; match to protein family HMM TIGR01859.
  
 
 0.930
ADK96781.1
Transketolase, thiamine diphosphate binding domain protein; Identified by match to protein family HMM PF00456; match to protein family HMM PF02779; match to protein family HMM PF02780; Belongs to the transketolase family.
  
 
 0.918
fbp
Firmicute fructose-1,6-bisphosphatase; Identified by match to protein family HMM PF06874.
     
 0.913
ADK96241.1
Kinase, PfkB family; Identified by match to protein family HMM PF00294.
  
 
 0.910
ADK95923.1
Kinase, PfkB family; Identified by match to protein family HMM PF00294.
  
 
 0.910
ADK95432.1
Putative mannose-6-phosphate isomerase, class I; Identified by match to protein family HMM PF01238.
    
 0.910
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
  
  
 
0.904
guaA
GMP synthase (glutamine-hydrolyzing) domain protein; Catalyzes the synthesis of GMP from XMP.
   
  
 0.853
pyk
Pyruvate kinase; Identified by match to protein family HMM PF00224; match to protein family HMM PF02887; match to protein family HMM TIGR01064; Belongs to the pyruvate kinase family.
 
 
 0.719
Your Current Organism:
Prevotella melaninogenica
NCBI taxonomy Id: 553174
Other names: P. melaninogenica ATCC 25845, Prevotella melaninogenica ATCC 25845, Prevotella melaninogenica CCUG 4944 B, Prevotella melaninogenica CIP 105346, Prevotella melaninogenica JCM 6325, Prevotella melaninogenica str. ATCC 25845, Prevotella melaninogenica strain ATCC 25845
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