node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EEN83082.1 | dut | POREN0001_0758 | POREN0001_1073 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.914 |
EEN83082.1 | folA | POREN0001_0758 | POREN0001_1760 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.533 |
EEN83082.1 | tdk | POREN0001_0758 | POREN0001_0543 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.846 |
EEN83082.1 | thyA | POREN0001_0758 | POREN0001_1759 | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.905 |
dut | EEN83082.1 | POREN0001_1073 | POREN0001_0758 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | 0.914 |
dut | folA | POREN0001_1073 | POREN0001_1760 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.596 |
dut | tdk | POREN0001_1073 | POREN0001_0543 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.931 |
dut | thyA | POREN0001_1073 | POREN0001_1759 | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.974 |
folA | EEN83082.1 | POREN0001_1760 | POREN0001_0758 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Cytidine and deoxycytidylate deaminase zinc-binding region; Identified by match to protein family HMM PF00383. | 0.533 |
folA | dut | POREN0001_1760 | POREN0001_1073 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.596 |
folA | folC | POREN0001_1760 | POREN0001_1330 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Bifunctional protein FolC; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | 0.947 |
folA | folD | POREN0001_1760 | POREN0001_1403 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.586 |
folA | gcvT | POREN0001_1760 | POREN0001_0880 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.888 |
folA | glyA | POREN0001_1760 | POREN0001_0886 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.906 |
folA | hisS | POREN0001_1760 | POREN0001_1761 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | histidine--tRNA ligase; Identified by match to protein family HMM PF00587; match to protein family HMM PF03129; match to protein family HMM TIGR00442. | 0.819 |
folA | tdk | POREN0001_1760 | POREN0001_0543 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidine kinase; Identified by match to protein family HMM PF00265. | 0.616 |
folA | thyA | POREN0001_1760 | POREN0001_1759 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.999 |
folC | folA | POREN0001_1330 | POREN0001_1760 | Bifunctional protein FolC; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. | 0.947 |
folC | folD | POREN0001_1330 | POREN0001_1403 | Bifunctional protein FolC; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.459 |
folC | glyA | POREN0001_1330 | POREN0001_0886 | Bifunctional protein FolC; Identified by match to protein family HMM PF08245; match to protein family HMM TIGR01499; Belongs to the folylpolyglutamate synthase family. | Glycine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.695 |