node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFF89143.1 | SFH01028.1 | SAMN04488063_0678 | SAMN04488063_3576 | L-threonine O-3-phosphate decarboxylase. | Phosphoserine phosphatase. | 0.554 |
SFF89143.1 | hisA | SAMN04488063_0678 | SAMN04488063_3530 | L-threonine O-3-phosphate decarboxylase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.912 |
SFF89143.1 | hisB | SAMN04488063_0678 | SAMN04488063_3537 | L-threonine O-3-phosphate decarboxylase. | Imidazoleglycerol-phosphate dehydratase. | 0.975 |
SFF89143.1 | hisC | SAMN04488063_0678 | SAMN04488063_1426 | L-threonine O-3-phosphate decarboxylase. | Histidinol-phosphate aminotransferase. | 0.768 |
SFF89143.1 | hisD | SAMN04488063_0678 | SAMN04488063_1946 | L-threonine O-3-phosphate decarboxylase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.953 |
SFF89143.1 | hisE | SAMN04488063_0678 | SAMN04488063_0529 | L-threonine O-3-phosphate decarboxylase. | phosphoribosyl-ATP pyrophosphatase. | 0.881 |
SFF89143.1 | hisF | SAMN04488063_0678 | SAMN04488063_1086 | L-threonine O-3-phosphate decarboxylase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.954 |
SFF89143.1 | hisG | SAMN04488063_0678 | SAMN04488063_0290 | L-threonine O-3-phosphate decarboxylase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.911 |
SFF89143.1 | hisH | SAMN04488063_0678 | SAMN04488063_0539 | L-threonine O-3-phosphate decarboxylase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.954 |
SFF89143.1 | hisI | SAMN04488063_0678 | SAMN04488063_3526 | L-threonine O-3-phosphate decarboxylase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.914 |
SFH01028.1 | SFF89143.1 | SAMN04488063_3576 | SAMN04488063_0678 | Phosphoserine phosphatase. | L-threonine O-3-phosphate decarboxylase. | 0.554 |
SFH01028.1 | hisA | SAMN04488063_3576 | SAMN04488063_3530 | Phosphoserine phosphatase. | 1-(5-phosphoribosyl)-5-[(5- phosphoribosylamino)methylideneamino] imidazole-4-carboxamide isomerase. | 0.843 |
SFH01028.1 | hisB | SAMN04488063_3576 | SAMN04488063_3537 | Phosphoserine phosphatase. | Imidazoleglycerol-phosphate dehydratase. | 0.857 |
SFH01028.1 | hisC | SAMN04488063_3576 | SAMN04488063_1426 | Phosphoserine phosphatase. | Histidinol-phosphate aminotransferase. | 0.554 |
SFH01028.1 | hisD | SAMN04488063_3576 | SAMN04488063_1946 | Phosphoserine phosphatase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.687 |
SFH01028.1 | hisE | SAMN04488063_3576 | SAMN04488063_0529 | Phosphoserine phosphatase. | phosphoribosyl-ATP pyrophosphatase. | 0.671 |
SFH01028.1 | hisF | SAMN04488063_3576 | SAMN04488063_1086 | Phosphoserine phosphatase. | Cyclase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.914 |
SFH01028.1 | hisG | SAMN04488063_3576 | SAMN04488063_0290 | Phosphoserine phosphatase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. Belongs to the ATP phosphoribosyltransferase family. Long subfamily. | 0.584 |
SFH01028.1 | hisH | SAMN04488063_3576 | SAMN04488063_0539 | Phosphoserine phosphatase. | Glutamine amidotransferase; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.845 |
SFH01028.1 | hisI | SAMN04488063_3576 | SAMN04488063_3526 | Phosphoserine phosphatase. | phosphoribosyl-AMP cyclohydrolase; Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP. | 0.857 |