STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFF93486.1Lon-B peptidase. Serine peptidase. MEROPS family S16; Belongs to the peptidase S16 family. (719 aa)    
Predicted Functional Partners:
grpE
Molecular chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP [...]
  
  
 0.905
dnaK
Molecular chaperone DnaK; Acts as a chaperone.
 
  
 0.851
SFF93521.1
Membrane protease YdiL, CAAX protease family.
       0.810
SFG63463.1
PDZ domain-containing protein.
 
   
 0.806
SFG42832.1
DNA modification methylase.
     
 0.798
rpl40e
Large subunit ribosomal protein L40e; Belongs to the eukaryotic ribosomal protein eL40 family.
  
  
  0.722
dnaJ
Molecular chaperone DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, [...]
 
  
 0.681
SFG57724.1
Hypothetical protein.
  
     0.675
SFG76970.1
Serine protease, S1-C subfamily, contains C-terminal PDZ domain.
    
 0.669
SFG39129.1
Small ribonucleoprotein.
  
  
  0.668
Your Current Organism:
Halopelagius inordinatus
NCBI taxonomy Id: 553467
Other names: CGMCC 1.7739, H. inordinatus, Halobacteriaceae archaeon RO5-14, Halobacteriaceae archaeon RO5-2, Halopelagius inordinatus Cui et al. 2010, JCM 15773, strain RO5-2
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