STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SFR35816.1Acetolactate synthase-1/2/3 large subunit; Belongs to the TPP enzyme family. (526 aa)    
Predicted Functional Partners:
SFR47935.1
Acetolactate synthase, small subunit.
 
 0.993
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
 
 0.966
SFR40832.1
Pyruvate kinase; Belongs to the pyruvate kinase family.
  
 0.884
SFR57473.1
Allosteric NADP-dependent malic enzyme.
  
 
 0.879
SFR33587.1
Pyruvate dehydrogenase E2 component (dihydrolipoamide acetyltransferase).
   
 
 0.868
SFR34113.1
2-oxoacid dehydrogenases acyltransferase (catalytic domain).
   
 
 0.868
ilvD
Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family.
 
 0.864
SFR47905.1
3-isopropylmalate dehydrogenase.
 
 0.833
SFR47911.1
3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit.
 
 
 0.801
SFR47917.1
3-isopropylmalate dehydratase, large subunit.
 
 
 0.766
Your Current Organism:
Halogeometricum rufum
NCBI taxonomy Id: 553469
Other names: CGMCC 1.7736, H. rufum, Halogeometricum rufum Cui et al. 2010, Halosarcina sp. RO1-4, Halosarcina sp. RO1-64, JCM 15770, strain RO1-4
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