node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
SFR39762.1 | SFR69648.1 | SAMN04487947_0903 | SAMN04487947_3656 | Hypothetical protein. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | 0.769 |
SFR39762.1 | thi4 | SAMN04487947_0903 | SAMN04487947_0906 | Hypothetical protein. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.513 |
SFR39762.1 | thiE | SAMN04487947_0903 | SAMN04487947_3658 | Hypothetical protein. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.774 |
SFR39793.1 | thi4 | SAMN04487947_0907 | SAMN04487947_0906 | Putative glutathione S-transferase. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.559 |
SFR43650.1 | thi4 | SAMN04487947_1421 | SAMN04487947_0906 | AMP phosphorylase. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.620 |
SFR62824.1 | thi4 | SAMN04487947_3026 | SAMN04487947_0906 | Bifunctional N6-L-threonylcarbamoyladenine synthase / protein kinase Bud32; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / Tsa [...] | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.640 |
SFR62824.1 | topA | SAMN04487947_3026 | SAMN04487947_0919 | Bifunctional N6-L-threonylcarbamoyladenine synthase / protein kinase Bud32; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / Tsa [...] | DNA topoisomerase-1; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.565 |
SFR69648.1 | SFR39762.1 | SAMN04487947_3656 | SAMN04487947_0903 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Hypothetical protein. | 0.769 |
SFR69648.1 | purO | SAMN04487947_3656 | SAMN04487947_0109 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.400 |
SFR69648.1 | thi4 | SAMN04487947_3656 | SAMN04487947_0906 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.886 |
SFR69648.1 | thiE | SAMN04487947_3656 | SAMN04487947_3658 | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.999 |
purO | SFR69648.1 | SAMN04487947_0109 | SAMN04487947_3656 | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | 0.400 |
purO | thi4 | SAMN04487947_0109 | SAMN04487947_0906 | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | 0.400 |
thi4 | SFR39762.1 | SAMN04487947_0906 | SAMN04487947_0903 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Hypothetical protein. | 0.513 |
thi4 | SFR39793.1 | SAMN04487947_0906 | SAMN04487947_0907 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Putative glutathione S-transferase. | 0.559 |
thi4 | SFR43650.1 | SAMN04487947_0906 | SAMN04487947_1421 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | AMP phosphorylase. | 0.620 |
thi4 | SFR62824.1 | SAMN04487947_0906 | SAMN04487947_3026 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Bifunctional N6-L-threonylcarbamoyladenine synthase / protein kinase Bud32; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is a component of the KEOPS complex that is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. The Kae1 domain likely plays a direct catalytic role in this reaction. The Bud32 domain probably displays kinase activity that regulates Kae1 function. In the N-terminal section; belongs to the KAE1 / Tsa [...] | 0.640 |
thi4 | SFR69648.1 | SAMN04487947_0906 | SAMN04487947_3656 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase. | 0.886 |
thi4 | purO | SAMN04487947_0906 | SAMN04487947_0109 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | IMP cyclohydrolase; Catalyzes the cyclization of 5-formylamidoimidazole-4- carboxamide ribonucleotide to IMP. | 0.400 |
thi4 | thiE | SAMN04487947_0906 | SAMN04487947_3658 | Thiazole-adenylate synthase; Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur. | Thiamine-phosphate diphosphorylase; Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). Belongs to the thiamine-phosphate synthase family. | 0.501 |