B7463_g8657 protein (Scytalidium lignicola) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

B7463_g8657

Uncharacterized protein. (2017 aa)

Predicted Functional Partners:

B7463_g641

0.837

B7463_g1845

0.785

B7463_g12636

0.627

B7463_g8474

0.627

B7463_g8189

0.627

B7463_g8547

0.627

B7463_g7243

0.627

B7463_g4926

0.627

B7463_g1899

0.627

B7463_g977

0.626

Your Current Organism:

Scytalidium lignicola

NCBI taxonomy Id: 5539
Other names: CBS 233.57, IMI 062532, MUCL 4172, S. lignicola, UAMH 385

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7463_g12636	B7463_g1845	A0A3E2GRH0	A0A3E2HM25	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.747
B7463_g12636	B7463_g1899	A0A3E2GRH0	A0A3E2HM62	Uncharacterized protein.	Uncharacterized protein.	0.766
B7463_g12636	B7463_g4926	A0A3E2GRH0	A0A3E2HDF1	Uncharacterized protein.	Uncharacterized protein.	0.761
B7463_g12636	B7463_g641	A0A3E2GRH0	A0A3E2HQP8	Uncharacterized protein.	Uncharacterized protein.	0.999
B7463_g12636	B7463_g7243	A0A3E2GRH0	A0A3E2H6T3	Uncharacterized protein.	Uncharacterized protein.	0.752
B7463_g12636	B7463_g8474	A0A3E2GRH0	A0A3E2H3A6	Uncharacterized protein.	Uncharacterized protein.	0.764
B7463_g12636	B7463_g8547	A0A3E2GRH0	A0A3E2H452	Uncharacterized protein.	Uncharacterized protein.	0.760
B7463_g12636	B7463_g8657	A0A3E2GRH0	A0A3E2H2Q1	Uncharacterized protein.	Uncharacterized protein.	0.627
B7463_g12636	B7463_g977	A0A3E2GRH0	A0A3E2HPW6	Uncharacterized protein.	Uncharacterized protein.	0.430
B7463_g1845	B7463_g12636	A0A3E2HM25	A0A3E2GRH0	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.747
B7463_g1845	B7463_g1899	A0A3E2HM25	A0A3E2HM62	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.670
B7463_g1845	B7463_g4926	A0A3E2HM25	A0A3E2HDF1	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.670
B7463_g1845	B7463_g7243	A0A3E2HM25	A0A3E2H6T3	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.670
B7463_g1845	B7463_g8189	A0A3E2HM25	A0A3E2H427	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.708
B7463_g1845	B7463_g8474	A0A3E2HM25	A0A3E2H3A6	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.670
B7463_g1845	B7463_g8547	A0A3E2HM25	A0A3E2H452	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.695
B7463_g1845	B7463_g8657	A0A3E2HM25	A0A3E2H2Q1	Profilin; Belongs to the profilin family.	Uncharacterized protein.	0.785
B7463_g1899	B7463_g12636	A0A3E2HM62	A0A3E2GRH0	Uncharacterized protein.	Uncharacterized protein.	0.766
B7463_g1899	B7463_g1845	A0A3E2HM62	A0A3E2HM25	Uncharacterized protein.	Profilin; Belongs to the profilin family.	0.670
B7463_g1899	B7463_g4926	A0A3E2HM62	A0A3E2HDF1	Uncharacterized protein.	Uncharacterized protein.	0.852

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.919

expected number of edges:

11

PPI enrichment p-value:

1.68e-05

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0032446

Protein modification by small protein conjugation

7 of 162

1.59

2.48

8.06e-08

GO:0019941

Modification-dependent protein catabolic process

8 of 228

1.5

2.32

4.99e-08

GO:0016567

Protein ubiquitination

6 of 141

1.58

2.17

1.46e-06

GO:0031146

SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

3 of 13

2.32

2.04

0.00013

GO:0006511

Ubiquitin-dependent protein catabolic process

6 of 219

1.39

1.64

1.56e-05

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0031625

Ubiquitin protein ligase binding

3 of 23

2.07

1.26

0.0039

GO:0030674

Protein-macromolecule adaptor activity

4 of 107

1.53

1.09

0.0039

GO:0019899

Enzyme binding

4 of 147

1.39

0.99

0.0047

GO:0031386

Protein tag

2 of 12

2.18

0.9

0.0214

GO:0005515

Protein binding

6 of 743

0.86

0.56

0.0151

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019005

SCF ubiquitin ligase complex

7 of 17

2.57

6.63

5.21e-14

GO:0000151

Ubiquitin ligase complex

8 of 82

1.94

4.52

2.32e-12

GO:0043224

Nuclear SCF ubiquitin ligase complex

2 of 4

2.65

1.48

0.0020

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:370

Mixed, incl. Protein neddylation, and SCF ubiquitin ligase complex

7 of 24

2.42

5.88

7.26e-13

CL:373

Protein neddylation, and SCF ubiquitin ligase complex

5 of 17

2.42

4.25

3.95e-09

CL:244

Class I MHC mediated antigen processing & presentation, and Neddylation

8 of 170

1.63

3.0

5.73e-10

CL:394

Nuclear SCF ubiquitin ligase complex, and SKP1 component, POZ domain

3 of 5

2.73

2.66

1.26e-05

CL:408

Mixed, incl. Leucine-rich repeat, cysteine-containing subtype, and SCF-dependent proteasomal ubiquitin-dependent protein catabolic process

2 of 5

2.56

1.28

0.0046

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map04120

Ubiquitin mediated proteolysis

7 of 119

1.72

3.14

2.18e-09

map04111

Cell cycle - yeast

7 of 122

1.71

3.12

2.18e-09

map04141

Protein processing in endoplasmic reticulum

3 of 176

1.18

0.59

0.0432

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983168

Antigen processing: Ubiquitination & Proteasome degradation

8 of 114

1.8

3.79

3.23e-11

MAP-983169

Class I MHC mediated antigen processing & presentation

9 of 170

1.68

3.5

8.62e-12

MAP-8951664

Neddylation

6 of 84

1.81

2.97

5.07e-08

MAP-1280218

Adaptive Immune System

9 of 243

1.52

2.84

6.54e-11

MAP-168256

Immune System

9 of 608

1.12

1.43

1.26e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0019005

SCF ubiquitin ligase complex

6 of 20

2.43

5.23

2.59e-11

GOCC:0031461

cullin-RING ubiquitin ligase complex

7 of 45

2.15

4.86

1.13e-11

GOCC:0000151

Ubiquitin ligase complex

8 of 80

1.95

4.48

4.38e-12

GOCC:1902494

Catalytic complex

9 of 747

1.03

1.2

7.79e-07

GOCC:0032991

Protein-containing complex

10 of 2189

0.61

0.51

0.00041

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR019956

Ubiquitin domain

2 of 6

2.48

0.76

0.0422

IPR019954

Ubiquitin conserved site

2 of 6

2.48

0.76

0.0422

IPR001810

F-box domain

4 of 142

1.4

0.67

0.0374

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00213

Ubiquitin homologues

2 of 16

2.05

0.81

0.0303

SM00256

A Receptor for Ubiquitination Targets

3 of 81

1.52

0.74

0.0303

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