B7463_g2617 protein (Scytalidium lignicola) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

B7463_g2617

Uncharacterized protein. (674 aa)

Predicted Functional Partners:

B7463_g4659

0.771

B7463_g1001

0.579

B7463_g6168

0.575

B7463_g7968

0.549

B7463_g1843

0.547

B7463_g6913

0.505

B7463_g4432

0.490

B7463_g2110

0.470

B7463_g11775

0.411

B7463_g11205

0.411

Your Current Organism:

Scytalidium lignicola

NCBI taxonomy Id: 5539
Other names: CBS 233.57, IMI 062532, MUCL 4172, S. lignicola, UAMH 385

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7463_g1001	B7463_g1843	A0A3E2HQV0	A0A3E2HMN4	Uncharacterized protein.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.853
B7463_g1001	B7463_g2617	A0A3E2HQV0	A0A3E2HJY1	Uncharacterized protein.	Uncharacterized protein.	0.579
B7463_g1001	B7463_g7968	A0A3E2HQV0	A0A3E2H4Q5	Uncharacterized protein.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.836
B7463_g11205	B7463_g2617	A0A3E2GVV9	A0A3E2HJY1	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.411
B7463_g11205	B7463_g4432	A0A3E2GVV9	A0A3E2HET9	WD_REPEATS_REGION domain-containing protein.	DOC domain-containing protein.	0.792
B7463_g11775	B7463_g2617	A0A3E2GTR5	A0A3E2HJY1	WD_REPEATS_REGION domain-containing protein.	Uncharacterized protein.	0.411
B7463_g11775	B7463_g4432	A0A3E2GTR5	A0A3E2HET9	WD_REPEATS_REGION domain-containing protein.	DOC domain-containing protein.	0.792
B7463_g1843	B7463_g1001	A0A3E2HMN4	A0A3E2HQV0	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.853
B7463_g1843	B7463_g2617	A0A3E2HMN4	A0A3E2HJY1	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein.	0.547
B7463_g1843	B7463_g7968	A0A3E2HMN4	A0A3E2H4Q5	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.781
B7463_g2110	B7463_g2617	A0A3E2HLE3	A0A3E2HJY1	Uncharacterized protein.	Uncharacterized protein.	0.470
B7463_g2110	B7463_g4659	A0A3E2HLE3	A0A3E2HET3	Uncharacterized protein.	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family.	0.536
B7463_g2617	B7463_g1001	A0A3E2HJY1	A0A3E2HQV0	Uncharacterized protein.	Uncharacterized protein.	0.579
B7463_g2617	B7463_g11205	A0A3E2HJY1	A0A3E2GVV9	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.411
B7463_g2617	B7463_g11775	A0A3E2HJY1	A0A3E2GTR5	Uncharacterized protein.	WD_REPEATS_REGION domain-containing protein.	0.411
B7463_g2617	B7463_g1843	A0A3E2HJY1	A0A3E2HMN4	Uncharacterized protein.	Uncharacterized protein; Belongs to the CDP-alcohol phosphatidyltransferase class-I family.	0.547
B7463_g2617	B7463_g2110	A0A3E2HJY1	A0A3E2HLE3	Uncharacterized protein.	Uncharacterized protein.	0.470
B7463_g2617	B7463_g4432	A0A3E2HJY1	A0A3E2HET9	Uncharacterized protein.	DOC domain-containing protein.	0.490
B7463_g2617	B7463_g4659	A0A3E2HJY1	A0A3E2HET3	Uncharacterized protein.	Uncharacterized protein; Belongs to the aldehyde dehydrogenase family.	0.771
B7463_g2617	B7463_g6168	A0A3E2HJY1	A0A3E2H9M8	Uncharacterized protein.	F-box domain-containing protein.	0.575

page 1 of 2

Network Stats

number of nodes:

4

number of edges:

6

average node degree:

3

avg. local clustering coefficient:

1

expected number of edges:

3

PPI enrichment p-value:

0.053

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006099

Tricarboxylic acid cycle

5 of 86

2.39

3.56

1.04e-07

GO:0006572

Tyrosine catabolic process

3 of 10

3.1

2.83

7.36e-06

GO:0006121

Mitochondrial electron transport, succinate to ubiquinone

3 of 10

3.1

2.83

7.36e-06

GO:0006559

L-phenylalanine catabolic process

3 of 15

2.93

2.7

1.18e-05

GO:0019752

Carboxylic acid metabolic process

5 of 1336

1.2

0.91

0.0033

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008177

Succinate dehydrogenase (ubiquinone) activity

3 of 7

3.26

3.0

3.66e-06

GO:0004411

Homogentisate 1,2-dioxygenase activity

2 of 2

3.63

2.01

0.00024

GO:0016823

Hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances

2 of 4

3.32

1.89

0.00039

GO:0009055

Electron transfer activity

3 of 117

2.03

1.55

0.00094

GO:0050660

Flavin adenine dinucleotide binding

3 of 184

1.84

1.26

0.0029

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

3 of 11

3.06

2.93

4.74e-06

GO:0070062

Extracellular exosome

3 of 139

1.96

1.59

0.00066

GO:0005739

Mitochondrion

8 of 2471

1.14

1.31

4.74e-06

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:54561

Tricarboxylic acid cycle

4 of 50

2.53

2.82

4.90e-06

CL:54569

Succinate dehydrogenase (ubiquinone) activity, and CoA binding domain

2 of 5

3.23

1.55

0.0016

CL:55624

Tyrosine catabolism, and 3-dehydroquinate synthase

2 of 6

3.15

1.51

0.0019

CL:54387

Mixed, incl. Fumarylacetoacetase-like, C-terminal, and Maleylacetoacetate isomerase activity

2 of 6

3.15

1.51

0.0019

CL:54627

Fumarate reductase complex, and succinate-CoA ligase activity

2 of 17

2.7

1.22

0.0061

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

map00350

Tyrosine metabolism

4 of 98

2.24

3.07

7.11e-07

map00020

Citrate cycle (TCA cycle)

4 of 121

2.14

2.92

1.08e-06

map01200

Carbon metabolism

5 of 434

1.69

2.32

1.62e-06

map00620

Pyruvate metabolism

3 of 148

1.93

1.79

0.00022

map00190

Oxidative phosphorylation

3 of 369

1.54

1.15

0.0027

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-71403

Citric acid cycle (TCA cycle)

5 of 65

2.51

4.27

5.18e-09

MAP-71406

Pyruvate metabolism and Citric Acid (TCA) cycle

5 of 131

2.21

3.47

7.64e-08

MAP-8963684

Tyrosine catabolism

3 of 10

3.1

3.19

1.58e-06

MAP-8963691

Phenylalanine and tyrosine metabolism

3 of 28

2.66

2.6

1.49e-05

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

5 of 364

1.76

2.26

5.74e-06

(more ...)

Tissue Expression (TISSUES)

tissue

description

count in network

strength

signal

false discovery rate

BTO:0000862

Heart ventricle

3 of 422

1.48

1.25

0.0011

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0005749

Mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)

3 of 9

3.15

2.99

3.74e-06

GOCC:0005739

Mitochondrion

5 of 1491

1.15

0.92

0.0021

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0816

Tricarboxylic acid cycle

2 of 16

2.72

1.41

0.0027

KW-0809

Transit peptide

2 of 29

2.46

1.3

0.0041

KW-0249

Electron transport

2 of 43

2.29

1.26

0.0046

KW-0560

Oxidoreductase

3 of 291

1.64

1.11

0.0046

KW-0274

FAD

2 of 76

2.05

1.04

0.0106

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF00890

FAD binding domain

3 of 14

2.96

2.54

2.31e-05

PF02910

Fumarate reductase flavoprotein C-term

2 of 2

3.63

1.82

0.00053

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR030664

FAD-dependent oxidoreductase SdhA/FrdA/AprA

3 of 4

3.5

3.03

3.45e-06

IPR003953

FAD-dependent oxidoreductase 2, FAD binding domain

3 of 4

3.5

3.03

3.45e-06

IPR046452

Homogentisate 1,2-dioxygenase, N-terminal domain

2 of 2

3.63

1.67

0.0010

IPR037099

Fumarate reductase/succinate dehydrogenase flavoprotein-like, C-terminal domain superfamily

2 of 2

3.63

1.67

0.0010

IPR027477

Succinate dehydrogenase/fumarate reductase flavoprotein, catalytic domain superfamily

2 of 2

3.63

1.67

0.0010

(more ...)

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