B7463_g2298 protein (Scytalidium lignicola) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

B7463_g2298

Uncharacterized protein. (630 aa)

Predicted Functional Partners:

B7463_g4314

0.636

B7463_g973

0.636

B7463_g2413

0.634

B7463_g228

0.631

B7463_g5972

0.612

B7463_g2808

0.596

B7463_g8394

0.593

B7463_g7965

0.543

B7463_g6653

0.543

B7463_g2749

0.543

Your Current Organism:

Scytalidium lignicola

NCBI taxonomy Id: 5539
Other names: CBS 233.57, IMI 062532, MUCL 4172, S. lignicola, UAMH 385

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
B7463_g228	B7463_g2298	A0A3E2HS27	A0A3E2HL00	Uncharacterized protein.	Uncharacterized protein.	0.631
B7463_g228	B7463_g2413	A0A3E2HS27	A0A3E2HL23	Uncharacterized protein.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.926
B7463_g228	B7463_g2808	A0A3E2HS27	A0A3E2HJI2	Uncharacterized protein.	ERCC4 domain-containing protein.	0.908
B7463_g228	B7463_g4314	A0A3E2HS27	A0A3E2HFA5	Uncharacterized protein.	MPN domain-containing protein.	0.923
B7463_g228	B7463_g8394	A0A3E2HS27	A0A3E2H3H1	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.966
B7463_g228	B7463_g973	A0A3E2HS27	A0A3E2HQS0	Uncharacterized protein.	NTF2 domain-containing protein.	0.923
B7463_g2298	B7463_g228	A0A3E2HL00	A0A3E2HS27	Uncharacterized protein.	Uncharacterized protein.	0.631
B7463_g2298	B7463_g2413	A0A3E2HL00	A0A3E2HL23	Uncharacterized protein.	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	0.634
B7463_g2298	B7463_g2749	A0A3E2HL00	A0A3E2HJK4	Uncharacterized protein.	Uncharacterized protein.	0.543
B7463_g2298	B7463_g2808	A0A3E2HL00	A0A3E2HJI2	Uncharacterized protein.	ERCC4 domain-containing protein.	0.596
B7463_g2298	B7463_g4314	A0A3E2HL00	A0A3E2HFA5	Uncharacterized protein.	MPN domain-containing protein.	0.636
B7463_g2298	B7463_g5972	A0A3E2HL00	A0A3E2HAM0	Uncharacterized protein.	Uncharacterized protein.	0.612
B7463_g2298	B7463_g6653	A0A3E2HL00	A0A3E2H8H8	Uncharacterized protein.	dUTPase domain-containing protein.	0.543
B7463_g2298	B7463_g7965	A0A3E2HL00	A0A3E2H4Q9	Uncharacterized protein.	Uncharacterized protein.	0.543
B7463_g2298	B7463_g8394	A0A3E2HL00	A0A3E2H3H1	Uncharacterized protein.	Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.	0.593
B7463_g2298	B7463_g973	A0A3E2HL00	A0A3E2HQS0	Uncharacterized protein.	NTF2 domain-containing protein.	0.636
B7463_g2413	B7463_g228	A0A3E2HL23	A0A3E2HS27	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Uncharacterized protein.	0.926
B7463_g2413	B7463_g2298	A0A3E2HL23	A0A3E2HL00	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	Uncharacterized protein.	0.634
B7463_g2413	B7463_g2808	A0A3E2HL23	A0A3E2HJI2	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	ERCC4 domain-containing protein.	0.964
B7463_g2413	B7463_g4314	A0A3E2HL23	A0A3E2HFA5	Ribosomal protein; Belongs to the universal ribosomal protein uL1 family.	MPN domain-containing protein.	0.961

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Network Stats

number of nodes:

11

number of edges:

50

average node degree:

9.09

avg. local clustering coefficient:

0.929

expected number of edges:

25

PPI enrichment p-value:

5.97e-06

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019646

Aerobic electron transport chain

10 of 44

2.5

9.29

7.54e-21

GO:0042775

Mitochondrial ATP synthesis coupled electron transport

10 of 47

2.47

9.19

7.54e-21

GO:0006122

Mitochondrial electron transport, ubiquinol to cytochrome c

6 of 12

2.84

6.64

2.44e-13

GO:0006123

Mitochondrial electron transport, cytochrome c to oxygen

4 of 10

2.75

3.84

6.75e-08

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0009055

Electron transfer activity

5 of 47

2.17

3.17

3.26e-07

GO:0015453

Oxidoreduction-driven active transmembrane transporter activity

4 of 35

2.2

2.51

1.13e-05

GO:0015078

Proton transmembrane transporter activity

3 of 54

1.89

1.27

0.0031

GO:0008121

Ubiquinol-cytochrome-c reductase activity

2 of 7

2.6

1.27

0.0047

GO:0016491

Oxidoreductase activity

6 of 577

1.16

1.05

0.00056

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0070069

Cytochrome complex

10 of 26

2.73

11.22

1.18e-23

GO:0098803

Respiratory chain complex

11 of 61

2.4

9.85

1.18e-23

GO:0005746

Mitochondrial respirasome

11 of 61

2.4

9.85

1.18e-23

GO:0098800

Inner mitochondrial membrane protein complex

11 of 101

2.18

8.16

4.09e-22

GO:0005750

Mitochondrial respiratory chain complex III

6 of 12

2.84

7.06

3.62e-14

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:39354118

(2024) Novel fungicide and neonicotinoid insecticide impair flight behavior in pollen foraging honey bees, Apis mellifera.

3 of 7

2.78

1.97

0.00025

PMID:31182611

(2019) Loss of the HIF pathway in a widely distributed intertidal crustacean, the copepod Tigriopus californicus.

2 of 6

2.67

0.72

0.0491

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:7906

Cytochrome complex

10 of 18

2.89

12.04

1.77e-24

CL:7841

Respiratory chain complex

11 of 55

2.44

10.21

4.72e-24

CL:7907

Respiratory chain complex III

7 of 11

2.95

8.53

6.41e-17

CL:7919

Respiratory chain complex III

4 of 5

3.05

4.58

3.96e-09

CL:7909

Respiratory chain complex III

3 of 5

2.92

3.01

3.09e-06

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

ame00190

Oxidative phosphorylation

11 of 86

2.25

8.83

4.86e-23

ame01100

Metabolic pathways

11 of 820

1.27

2.16

7.47e-13

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-611105

Respiratory electron transport

11 of 93

2.22

8.25

1.12e-21

MAP-163200

Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins.

11 of 111

2.14

7.68

3.52e-21

MAP-1428517

The citric acid (TCA) cycle and respiratory electron transport

11 of 179

1.93

6.03

3.63e-19

MAP-9707564

Cytoprotection by HMOX1

4 of 52

2.03

2.36

1.42e-05

MAP-5628897

TP53 Regulates Metabolic Genes

4 of 72

1.89

2.06

4.11e-05

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0070069

Cytochrome complex

8 of 23

2.69

8.34

2.41e-17

GOCC:0070469

Respirasome

9 of 65

2.29

7.19

3.29e-17

GOCC:0005746

Mitochondrial respirasome

8 of 45

2.39

7.0

8.98e-16

GOCC:0098803

Respiratory chain complex

8 of 47

2.37

6.95

9.25e-16

GOCC:0005750

Mitochondrial respiratory chain complex III

5 of 10

2.84

5.66

2.29e-11

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0679

Respiratory chain

2 of 9

2.49

1.16

0.0074

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