MPER_03860 protein (Moniliophthora perniciosa)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

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[Homology]

Score

MPER_03860

Uncharacterized protein. (203 aa)

Predicted Functional Partners:

MPER_09071

0.994

MPER_06800

0.942

MPER_01850

0.925

MPER_08522

0.925

MPER_15212

0.925

MPER_00918

0.892

MPER_10210

0.882

MPER_02159

0.812

MPER_10870

0.794

MPER_13849

0.794

Your Current Organism:

Moniliophthora perniciosa

NCBI taxonomy Id: 554373
Other names: M. perniciosa FA553, Moniliophthora perniciosa FA553

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MPER_00918	MPER_01850	E2L589	E2L7I9	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.886
MPER_00918	MPER_02159	E2L589	E2L8A3	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	TruB_N domain-containing protein.	0.542
MPER_00918	MPER_03860	E2L589	E2LCD4	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.892
MPER_00918	MPER_08522	E2L589	E2LNV5	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.886
MPER_00918	MPER_09071	E2L589	E2LQ80	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	Uncharacterized protein.	0.892
MPER_00918	MPER_15212	E2L589	E2M4G9	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	IBB domain-containing protein.	0.886
MPER_01850	MPER_00918	E2L7I9	E2L589	Uncharacterized protein.	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	0.886
MPER_01850	MPER_03860	E2L7I9	E2LCD4	Uncharacterized protein.	Uncharacterized protein.	0.925
MPER_01850	MPER_06800	E2L7I9	E2LJL0	Uncharacterized protein.	RanBD1 domain-containing protein.	0.894
MPER_01850	MPER_09071	E2L7I9	E2LQ80	Uncharacterized protein.	Uncharacterized protein.	0.925
MPER_01850	MPER_10210	E2L7I9	E2LT23	Uncharacterized protein.	Uncharacterized protein.	0.876
MPER_02159	MPER_00918	E2L8A3	E2L589	TruB_N domain-containing protein.	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	0.542
MPER_02159	MPER_03860	E2L8A3	E2LCD4	TruB_N domain-containing protein.	Uncharacterized protein.	0.812
MPER_02159	MPER_09071	E2L8A3	E2LQ80	TruB_N domain-containing protein.	Uncharacterized protein.	0.812
MPER_02159	MPER_10210	E2L8A3	E2LT23	TruB_N domain-containing protein.	Uncharacterized protein.	0.402
MPER_03860	MPER_00918	E2LCD4	E2L589	Uncharacterized protein.	Ribosomal RNA-processing protein 8; S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2. Belongs to the methyltransferase superfamily. RRP8 family.	0.892
MPER_03860	MPER_01850	E2LCD4	E2L7I9	Uncharacterized protein.	Uncharacterized protein.	0.925
MPER_03860	MPER_02159	E2LCD4	E2L8A3	Uncharacterized protein.	TruB_N domain-containing protein.	0.812
MPER_03860	MPER_06800	E2LCD4	E2LJL0	Uncharacterized protein.	RanBD1 domain-containing protein.	0.942
MPER_03860	MPER_08522	E2LCD4	E2LNV5	Uncharacterized protein.	Uncharacterized protein.	0.925

page 1 of 4

Network Stats

number of nodes:

11

number of edges:

27

average node degree:

4.91

avg. local clustering coefficient:

0.783

expected number of edges:

12

PPI enrichment p-value:

0.00012

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0007018

Microtubule-based movement

6 of 308

1.61

1.88

2.26e-05

GO:0046586

Regulation of calcium-dependent cell-cell adhesion

2 of 2

3.32

1.5

0.0020

GO:0007406

Negative regulation of neuroblast proliferation

2 of 3

3.14

1.42

0.0028

GO:0000070

Mitotic sister chromatid segregation

3 of 88

1.85

1.05

0.0089

GO:0070229

Negative regulation of lymphocyte apoptotic process

2 of 11

2.58

1.05

0.0121

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008574

Plus-end-directed microtubule motor activity

3 of 21

2.47

1.8

0.00045

GO:0019894

Kinesin binding

3 of 40

2.19

1.6

0.00090

GO:0120170

Intraciliary transport particle B binding

2 of 4

3.02

1.48

0.0021

GO:0008017

Microtubule binding

4 of 271

1.49

1.09

0.0034

GO:0008092

Cytoskeletal protein binding

7 of 1110

1.12

1.02

0.00045

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005871

Kinesin complex

4 of 63

2.12

2.42

1.38e-05

GO:0016939

Kinesin II complex

2 of 2

3.32

2.04

0.00021

GO:0005828

Kinetochore microtubule

2 of 4

3.02

1.9

0.00036

GO:0097730

Non-motile cilium

4 of 123

1.83

1.84

0.00012

GO:0005876

Spindle microtubule

3 of 49

2.1

1.84

0.00025

(more ...)

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:17888

Intraciliary transport particle, and Kinesin II complex

4 of 27

2.49

2.82

4.52e-06

CL:8090

Mixed, incl. Mitotic spindle midzone, and Spindle elongation

3 of 13

2.68

2.51

2.31e-05

CL:17865

Mixed, incl. Transport along microtubule, and Kinesins

5 of 175

1.77

2.18

1.06e-05

CL:17932

Kinesin II complex, and Microtubule anchoring at centrosome

2 of 5

2.92

1.61

0.0012

CL:17896

Intraciliary transport particle B

2 of 5

2.92

1.61

0.0012

(more ...)

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-983189

Kinesins

6 of 98

2.1

3.79

5.77e-09

MAP-6811434

COPI-dependent Golgi-to-ER retrograde traffic

6 of 161

1.89

3.11

5.17e-08

MAP-8856688

Golgi-to-ER retrograde transport

6 of 191

1.81

2.9

9.36e-08

MAP-2132295

MHC class II antigen presentation

6 of 213

1.77

2.77

1.33e-07

MAP-983231

Factors involved in megakaryocyte development and platelet production

6 of 217

1.76

2.76

1.33e-07

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016939

Kinesin II complex

2 of 3

3.14

1.66

0.0010

GOCC:0005871

Kinesin complex

3 of 43

2.16

1.58

0.00095

GOCC:0015630

Microtubule cytoskeleton

6 of 556

1.35

1.38

0.00014

GOCC:0051233

Spindle midzone

2 of 12

2.54

1.25

0.0052

GOCC:0005876

Spindle microtubule

2 of 17

2.39

1.17

0.0069

(more ...)

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0505

Motor protein

4 of 118

1.85

1.91

8.26e-05

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF01088

Ubiquitin carboxyl-terminal hydrolase, family 1

2 of 4

3.02

1.19

0.0072

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR001752

Kinesin motor domain

4 of 54

2.19

2.09

8.61e-05

IPR036961

Kinesin motor domain superfamily

4 of 109

1.88

1.57

0.00064

IPR041507

Peptidase C12, C-terminal domain

2 of 2

3.32

1.46

0.0024

IPR008658

Kinesin-associated protein 3

2 of 2

3.32

1.46

0.0024

IPR027640

Kinesin-like protein

3 of 40

2.19

1.39

0.0024

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00129

Kinesin motor, catalytic domain. ATPase.

4 of 51

2.21

2.59

7.58e-06

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