MPER_07618 protein (Moniliophthora perniciosa)

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Known Interactions

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Predicted Interactions

gene neighborhood

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Score

MPER_07618

NOSIC domain-containing protein. (211 aa)

Predicted Functional Partners:

MPER_08271

0.973

LSM8

0.965

MPER_14135

0.963

MPER_12071

0.948

MPER_06422

0.943

MPER_03303

0.936

MPER_14435

0.929

MPER_05545

0.927

MPER_15190

0.918

MPER_11418

0.906

Your Current Organism:

Moniliophthora perniciosa

NCBI taxonomy Id: 554373
Other names: M. perniciosa FA553, Moniliophthora perniciosa FA553

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LSM8	MPER_03303	E2LIW7	E2LB13	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.937
LSM8	MPER_05545	E2LIW7	E2LGG9	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.993
LSM8	MPER_06422	E2LIW7	E2LIN1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	C2H2-type domain-containing protein.	0.968
LSM8	MPER_07618	E2LIW7	E2LLL1	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	NOSIC domain-containing protein.	0.965
LSM8	MPER_08271	E2LIW7	E2LN81	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	PRP3 domain-containing protein.	0.998
LSM8	MPER_11418	E2LIW7	E2LW18	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.978
LSM8	MPER_12071	E2LIW7	E2LXQ4	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Prp31_C domain-containing protein.	0.998
LSM8	MPER_14135	E2LIW7	E2M2C8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.994
LSM8	MPER_14435	E2LIW7	E2M2W2	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.996
LSM8	MPER_15190	E2LIW7	E2M4E8	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	Uncharacterized protein.	0.634
MPER_03303	LSM8	E2LB13	E2LIW7	Uncharacterized protein.	U6 snRNA-associated Sm-like protein LSm8; Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA.	0.937
MPER_03303	MPER_05545	E2LB13	E2LGG9	Uncharacterized protein.	Uncharacterized protein.	0.991
MPER_03303	MPER_06422	E2LB13	E2LIN1	Uncharacterized protein.	C2H2-type domain-containing protein.	0.999
MPER_03303	MPER_07618	E2LB13	E2LLL1	Uncharacterized protein.	NOSIC domain-containing protein.	0.936
MPER_03303	MPER_08271	E2LB13	E2LN81	Uncharacterized protein.	PRP3 domain-containing protein.	0.986
MPER_03303	MPER_11418	E2LB13	E2LW18	Uncharacterized protein.	Uncharacterized protein.	0.998
MPER_03303	MPER_12071	E2LB13	E2LXQ4	Uncharacterized protein.	Prp31_C domain-containing protein.	0.990
MPER_03303	MPER_14135	E2LB13	E2M2C8	Uncharacterized protein.	Uncharacterized protein.	0.995
MPER_03303	MPER_14435	E2LB13	E2M2W2	Uncharacterized protein.	Uncharacterized protein.	0.995
MPER_03303	MPER_15190	E2LB13	E2M4E8	Uncharacterized protein.	Uncharacterized protein.	0.743

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Network Stats

number of nodes:

11

number of edges:

32

average node degree:

5.82

avg. local clustering coefficient:

0.714

expected number of edges:

25

PPI enrichment p-value:

0.0932

your network does not have significantly more
interactions than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0008380

RNA splicing

10 of 335

1.79

4.36

4.73e-14

GO:0006397

mRNA processing

10 of 420

1.69

3.84

2.19e-13

GO:0000398

mRNA splicing, via spliceosome

7 of 217

1.83

3.34

3.40e-09

GO:0051028

mRNA transport

4 of 90

1.97

2.11

4.38e-05

GO:0010467

Gene expression

11 of 1665

1.14

1.61

5.16e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0003723

RNA binding

11 of 1169

1.29

2.14

1.77e-11

GO:0003729

mRNA binding

4 of 282

1.47

1.06

0.0040

GO:0000339

RNA cap binding

2 of 16

2.41

1.01

0.0143

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005846

Nuclear cap binding complex

2 of 2

3.32

1.55

0.0016

GO:0016607

Nuclear speck

4 of 269

1.49

1.18

0.0019

GO:0002102

Podosome

2 of 18

2.36

1.16

0.0072

GO:0016604

Nuclear body

5 of 483

1.33

1.09

0.0016

GO:0005681

Spliceosomal complex

3 of 167

1.57

0.97

0.0089

(more ...)

Reference Publications (PubMed)

publication

(year) title

count in network

strength

signal

false discovery rate

PMID:37941135

(2023) Alternative splicing induced by bacterial pore-forming toxins sharpens CIRBP-mediated cell response to Listeria infection.

2 of 15

2.44

0.89

0.0234

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:2649

RNA Polymerase II Transcription Termination, and mRNA Splicing - Major Pathway

11 of 130

2.25

8.36

1.64e-21

CL:2657

RNA recognition motif domain

8 of 71

2.37

6.63

5.76e-15

CL:2737

mRNA 3-end processing

4 of 22

2.58

3.37

4.30e-07

CL:2739

Mixed, incl. SRSF7, RNA recognition motif, and SRSF1, RNA recognition motif 1

3 of 13

2.68

2.46

2.89e-05

CL:2665

Mixed, incl. ROK, N-terminal, and TAF15/EWS/TLS family

3 of 13

2.68

2.46

2.89e-05

(more ...)

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

pret03040

Spliceosome

9 of 120

2.19

6.81

3.94e-17

pret03015

mRNA surveillance pathway

3 of 76

1.91

1.63

0.00050

pret05168

Herpes simplex virus 1 infection

4 of 268

1.49

1.37

0.00050

pret03013

RNA transport

3 of 136

1.66

1.31

0.0015

Reactome Pathways

pathway

description

count in network

strength

signal

false discovery rate

MAP-72163

mRNA Splicing - Major Pathway

11 of 251

1.96

6.14

6.02e-19

MAP-72172

mRNA Splicing

11 of 272

1.92

5.93

7.14e-19

MAP-73856

RNA Polymerase II Transcription Termination

7 of 78

2.27

5.56

8.26e-13

MAP-72203

Processing of Capped Intron-Containing Pre-mRNA

11 of 362

1.8

5.04

1.04e-17

MAP-72187

mRNA 3-end processing

6 of 67

2.27

4.73

1.08e-10

(more ...)

Subcellular Localization (COMPARTMENTS)

compartment

description

count in network

strength

signal

false discovery rate

GOCC:0016607

Nuclear speck

4 of 79

2.02

2.03

8.00e-05

GOCC:0005846

Nuclear cap binding complex

2 of 3

3.14

1.64

0.0011

GOCC:0002102

Podosome

2 of 25

2.22

0.89

0.0225

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0694

RNA-binding

8 of 325

1.71

3.4

9.87e-11

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR000504

RNA recognition motif domain

8 of 233

1.85

3.77

1.54e-10

IPR035979

RNA-binding domain superfamily

8 of 257

1.81

3.65

1.66e-10

IPR012677

Nucleotide-binding alpha-beta plait domain superfamily

8 of 264

1.8

3.62

1.66e-10

IPR012987

ROK, N-terminal

2 of 2

3.32

1.48

0.0022

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM00360

RNA recognition motif

8 of 227

1.86

4.08

1.38e-11

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