MPER_08666 protein (Moniliophthora perniciosa)

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second shell of interactors

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Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

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[Homology]

Score

MPER_08666

WD_REPEATS_REGION domain-containing protein. (243 aa)

Predicted Functional Partners:

MPER_01283

0.600

MPER_00768

0.524

MPER_08308

0.515

MPER_15948

0.511

MPER_12495

0.505

MPER_05840

0.504

MPER_07659

0.497

MPER_15301

0.496

MPER_07693

0.471

MPER_01596

0.470

Your Current Organism:

Moniliophthora perniciosa

NCBI taxonomy Id: 554373
Other names: M. perniciosa FA553, Moniliophthora perniciosa FA553

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
MPER_00768	MPER_01283	E2L4W2	E2L652	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.675
MPER_00768	MPER_01596	E2L4W2	E2L6W9	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.486
MPER_00768	MPER_05840	E2L4W2	E2LH76	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.665
MPER_00768	MPER_07659	E2L4W2	E2LLP9	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.556
MPER_00768	MPER_08666	E2L4W2	E2LP73	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.524
MPER_00768	MPER_15301	E2L4W2	E2M4P0	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.513
MPER_01283	MPER_00768	E2L652	E2L4W2	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.675
MPER_01283	MPER_01596	E2L652	E2L6W9	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.502
MPER_01283	MPER_05840	E2L652	E2LH76	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.555
MPER_01283	MPER_07659	E2L652	E2LLP9	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.502
MPER_01283	MPER_07693	E2L652	E2LLT2	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.574
MPER_01283	MPER_08308	E2L652	E2LNB6	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.533
MPER_01283	MPER_08666	E2L652	E2LP73	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.600
MPER_01283	MPER_15301	E2L652	E2M4P0	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.503
MPER_01596	MPER_00768	E2L6W9	E2L4W2	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.486
MPER_01596	MPER_01283	E2L6W9	E2L652	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.502
MPER_01596	MPER_05840	E2L6W9	E2LH76	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.508
MPER_01596	MPER_07659	E2L6W9	E2LLP9	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.546
MPER_01596	MPER_07693	E2L6W9	E2LLT2	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.401
MPER_01596	MPER_08308	E2L6W9	E2LNB6	WD_REPEATS_REGION domain-containing protein.	WD_REPEATS_REGION domain-containing protein.	0.951

page 1 of 5

Network Stats

number of nodes:

11

number of edges:

35

average node degree:

6.36

avg. local clustering coefficient:

0.817

expected number of edges:

11

PPI enrichment p-value:

4.89e-09

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0019363

Pyridine nucleotide biosynthetic process

7 of 15

2.2

4.82

3.07e-11

GO:0019359

Nicotinamide nucleotide biosynthetic process

6 of 14

2.16

4.23

7.46e-10

GO:0009435

NAD biosynthetic process

5 of 12

2.15

3.54

3.73e-08

GO:0009165

Nucleotide biosynthetic process

8 of 77

1.55

2.73

1.11e-09

GO:0009117

Nucleotide metabolic process

9 of 111

1.44

2.49

3.08e-10

(more ...)

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0004514

Nicotinate-nucleotide diphosphorylase (carboxylating) activity

3 of 3

2.53

1.95

0.00024

GO:0004516

Nicotinate phosphoribosyltransferase activity

2 of 2

2.53

1.1

0.0099

GO:0016879

Ligase activity, forming carbon-nitrogen bonds

3 of 40

1.41

0.69

0.0346

GO:0016740

Transferase activity

7 of 544

0.64

0.39

0.0346

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

9 of 1020

0.48

0.32

0.0314

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:1329

Mixed, incl. Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

10 of 29

2.07

6.28

3.84e-17

CL:1330

Mixed, incl. Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

9 of 22

2.14

6.17

1.14e-15

CL:1333

Nicotinate and nicotinamide metabolism

6 of 6

2.53

5.39

2.31e-11

CL:1331

Nicotinate and nicotinamide metabolism, and AraR-like, winged helix DNA-binding domain

7 of 16

2.17

4.93

1.08e-11

CL:1362

Mixed, incl. GDP metabolic process, and Cytidyltransferase-like domain

2 of 6

2.06

0.77

0.0367

KEGG Pathways

pathway

description

count in network

strength

signal

false discovery rate

mtt00760

Nicotinate and nicotinamide metabolism

10 of 15

2.36

8.53

2.54e-20

mtt01100

Metabolic pathways

10 of 566

0.78

0.77

3.44e-06

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0520

NAD

4 of 45

1.48

1.2

0.0016

KW-0328

Glycosyltransferase

3 of 27

1.58

1.01

0.0072

KW-0662

Pyridine nucleotide biosynthesis

2 of 7

1.99

0.92

0.0184

KW-0547

Nucleotide-binding

5 of 286

0.78

0.45

0.0349

KW-0808

Transferase

6 of 436

0.67

0.4

0.0349

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF04095

Nicotinate phosphoribosyltransferase (NAPRTase) family

2 of 2

2.53

0.88

0.0248

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR036068

Nicotinate phosphoribosyltransferase-like, C-terminal

3 of 3

2.53

1.79

0.00049

IPR041525

Nicotinate/nicotinamide phosphoribosyltransferase

2 of 2

2.53

0.83

0.0310

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