Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Toce_0005Protein of unknown function DUF721; InterPro IPR007922; KEGG: gsu:GSU0638 hypothetical protein; PFAM: protein of unknown function DUF721; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function (DUF721). (161 aa)    
Predicted Functional Partners:
recF
DNA replication and repair protein RecF; The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP.
  
  
 0.824
Toce_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
     
 0.814
Toce_0003
RNA-binding S4 domain protein; COGs: COG2501 conserved hypothetical protein; InterPro IPR002942; KEGG: cac:CAC0003 hypothetical protein; PFAM: RNA-binding S4 domain protein; SMART: RNA-binding S4 domain protein; SPTR: Putative uncharacterized protein; PFAM: S4 domain.
       0.794
Toce_0006
KEGG: dae:Dtox_0005 hypothetical protein; SPTR: Putative uncharacterized protein.
       0.794
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
   
   0.784
gyrA
DNA gyrase subunit A; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
       0.721
Toce_2167
COGs: COG1538 Outer membrane protein; InterPro IPR003423; KEGG: bbe:BBR47_54170 hypothetical protein; PFAM: outer membrane efflux protein; SPTR: Putative uncharacterized protein; PFAM: Outer membrane efflux protein.
  
     0.588
Toce_1367
Von Willebrand factor type A; COGs: COG1240 Mg-chelatase subunit ChlD; InterPro IPR002035; KEGG: nth:Nther_2026 von Willebrand factor type A; PFAM: von Willebrand factor type A; SMART: von Willebrand factor type A; SPTR: Von Willebrand factor, type A; PFAM: von Willebrand factor type A domain.
  
     0.537
dnaA
Chromosomal replication initiator protein DnaA; Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'- TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. Belongs to the DnaA family.
       0.475
Toce_0631
KEGG: tte:TTE0927 hypothetical protein; SPTR: Putative uncharacterized protein.
  
     0.448
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.