Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Toce_0025Transcriptional regulator, AbrB family; InterPro IPR006339:IPR007159; KEGG: cac:CAC3647 transition state regulatory protein AbrB; PFAM: SpoVT/AbrB domain protein; SPTR: Transition state regulatory protein AbrB; TIGRFAM: transcriptional regulator, AbrB family; PFAM: SpoVT / AbrB like domain; TIGRFAM: looped-hinge helix DNA binding domain, AbrB family. (83 aa)    
Predicted Functional Partners:
Toce_1300
Sporulation transcriptional activator Spo0A; May play the central regulatory role in sporulation. It may be an element of the effector pathway responsible for the activation of sporulation genes in response to nutritional stress. Spo0A may act in concert with spo0H (a sigma factor) to control the expression of some genes that are critical to the sporulation process.
  
   
 0.802
Toce_2013
InterPro IPR018356:IPR014208; KEGG: hor:Hore_17740 sporulation stage III transcriptional regulator SpoIIID; SPTR: Sporulation stage III transcriptional regulator SpoIIID; TIGRFAM: sporulation transcriptional regulator SpoIIID; PFAM: Stage III sporulation protein D; TIGRFAM: sporulation transcriptional regulator SpoIIID.
  
   
 0.738
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
  
 0.728
Toce_0980
Stage IV sporulation protein A; ATPase. Has a role at an early stage in the morphogenesis of the spore coat.
  
   
 0.713
Toce_1320
Stage III sporulation protein AC; InterPro IPR009570:IPR005829; KEGG: amt:Amet_2494 stage III sporulation AC family protein; SPTR: Stage III sporulation AC family protein; TIGRFAM: stage III sporulation protein AC; PFAM: Stage III sporulation protein AC/AD protein family; TIGRFAM: stage III sporulation protein AC.
  
   
 0.666
Toce_1262
Stage V sporulation protein AE; InterPro IPR014204:IPR005562; KEGG: csc:Csac_0090 SpoVA protein; PFAM: SpoVA protein; SPTR: SpoVA protein; TIGRFAM: stage V sporulation protein AE; PFAM: SpoVA protein; TIGRFAM: stage V sporulation protein AE.
  
     0.631
Toce_0026
NurA domain protein; InterPro IPR018977; KEGG: bcl:ABC0059 hypothetical protein; PFAM: NurA domain; SPTR: NurA domain superfamily; PFAM: NurA domain.
       0.579
Toce_1264
Stage V sporulation protein AC; InterPro IPR014203:IPR005562; KEGG: cdl:CDR20291_0702 stage V sporulation protein AC; PFAM: SpoVA protein; SPTR: Putative uncharacterized protein; TIGRFAM: stage V sporulation protein AC; PFAM: SpoVA protein; TIGRFAM: stage V sporulation protein AC.
  
     0.579
Toce_2204
InterPro IPR004995; KEGG: tit:Thit_2223 GerA spore germination protein; PFAM: GerA spore germination protein; SPTR: GerA spore germination protein; PFAM: Bacillus/Clostridium GerA spore germination protein.
  
   
 0.577
Toce_0962
RNA polymerase, sigma subunit, RpsG/SigG; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
   
 0.566
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.