STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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prsRibose-phosphate pyrophosphokinase; Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib- 5-P); Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily. (312 aa)    
Predicted Functional Partners:
glmU
Glucosamine-1-phosphate N-acetyltransferase; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain.
  
 0.997
Toce_1431
Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: tte:TTE0187 thiamine pyrophosphate-dependent dehydrogenase, E1 component beta subunit; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Thiamine pyrophosphate-dependent dehydrogenases, E1 component beta subunit; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
   
 0.973
Toce_2030
Transketolase central region; COGs: COG0022 Pyruvate/2-oxoglutarate dehydrogenase complex dehydrogenase (E1) component eukaryotic type beta subunit; InterPro IPR005475:IPR005476; KEGG: tex:Teth514_2032 transketolase, central region; PFAM: Transketolase central region; Transketolase domain protein; SPTR: Transketolase, pyridine binding domain protein; PFAM: Transketolase, C-terminal domain; Transketolase, pyrimidine binding domain.
   
 0.973
purF
Amidophosphoribosyltransferase; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
  
 0.936
Toce_1430
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR000089:IPR004167:IPR001078; KEGG: tte:TTE0188 dihydrolipoamide acyltransferase; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: 2-oxo acid dehydrogenases acyltransferase (Catalytic domain) protein; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 binding domain; Biotin-requi [...]
   
 0.933
Toce_2028
Catalytic domain of components of various dehydrogenase complexes; COGs: COG0508 Pyruvate/2-oxoglutarate dehydrogenase complex dihydrolipoamide acyltransferase (E2) protein; InterPro IPR003016:IPR000089:IPR004167:IPR001078; KEGG: tex:Teth514_2030 dehydrogenase catalytic domain-containing protein; PFAM: catalytic domain of components of various dehydrogenase complexes; biotin/lipoyl attachment domain-containing protein; E3 binding domain protein; SPTR: Catalytic domain of components of various dehydrogenase complexes; PFAM: 2-oxoacid dehydrogenases acyltransferase (catalytic domain); e3 [...]
   
 0.933
Toce_0825
COGs: COG1109 Phosphomannomutase; InterProIPR016066:IPR005841:IPR005844:IPR005845:IPR 005846:IPR005843; KEGG: tte:TTE0731 phosphomannomutase; PFAM: phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain I; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain II; phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III; phosphoglucomutase/phosphomannomutase; SPTR: Phosphomannomutase; PFAM: Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain II; Phosphoglucomutase/phosphomannomutase, alpha/beta/alpha domain III; Phosphoglucomutase/phosphomannomutase, C [...]
  
 0.932
Toce_2066
COGs: COG0698 Ribose 5-phosphate isomerase RpiB; InterPro IPR004785:IPR003500; KEGG: gyc:GYMC61_3427 sugar-phosphate isomerase, RpiB/LacA/LacB family; PFAM: Ribose/galactose isomerase; PRIAM: Ribose-5-phosphate isomerase; SPTR: Ribose 5-phosphate isomerase; TIGRFAM: sugar-phosphate isomerase, RpiB/LacA/LacB family; ribose 5-phosphate isomerase B; PFAM: Ribose/Galactose Isomerase; TIGRFAM: ribose 5-phosphate isomerase B; ribose 5-phosphate isomerase; sugar-phosphate isomerases, RpiB/LacA/LacB family.
    
 0.929
rplY
Ribosomal 5S rRNA E-loop binding protein Ctc/L25/TL5; This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.
  
  
 0.925
Toce_1274
NUDIX hydrolase; InterPro IPR000086:IPR020084; KEGG: tte:TTE1310 NTP pyrophosphohydrolase including oxidative damage repair enzyme; PFAM: NUDIX hydrolase; SPTR: NTP pyrophosphohydrolases including oxidative damage repair enzymes; PFAM: NUDIX domain; TIGRFAM: nudix hydrolase, YffH family.
  
 
 0.918
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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