close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
cas2CRISPR-associated protein, Cas2 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette. (87 aa)    
Predicted Functional Partners:
cas1
CRISPR-associated protein, Cas1 family; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.
 
 0.999
Toce_0073
CRISPR-associated exonuclease, Cas4 family; CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Belongs to the CRISPR-associated exonuclease Cas4 family.
 
 
 
 0.995
Toce_0072
CRISPR-associated HD domain protein; COGs: COG1203 helicase; InterProIPR006483:IPR006474:IPR006935:IPR001650:IPR 014001; KEGG: pth:PTH_1916 helicases; PFAM: type III restriction protein res subunit; helicase domain protein; SMART: DEAD-like helicase; helicase domain protein; SPTR: Predicted helicases; TIGRFAM: CRISPR-associated HD domain protein; CRISPR-associated helicase Cas3; PFAM: DEAD/DEAH box helicase; TIGRFAM: CRISPR-associated helicase Cas3.
 
  
 0.946
Toce_1305
KEGG: drm:Dred_1080 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 
 0.890
Toce_0068
CRISPR-associated protein Cas6; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
 
   
 0.876
Toce_0079
CRISPR-associated protein Cas6; CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).
 
   
 0.876
Toce_0070
CRISPR-associated protein, Csh2 family; COGs: COG3649 Uncharacterized protein predicted to be involved in DNA repair; InterPro IPR006482; KEGG: pth:PTH_1918 hypothetical protein; PFAM: CRISPR-associated protein TM1801; SPTR: Uncharacterized protein; TIGRFAM: CRISPR-associated protein, CT1132 family; PFAM: Family of unknown function (DUF694); TIGRFAM: CRISPR-associated protein, CT1132 family; CRISPR-associated protein, Csh2 family.
 
   
 0.872
Toce_0071
InterPro IPR013422; KEGG: CRISPR-associated protein Cas5; SPTR: Putative uncharacterized protein; TIGRFAM: CRISPR-associated protein Cas5; PFAM: CRISPR-associated protein (Cas_Cas5); TIGRFAM: CRISPR-associated protein Cas5, Hmari subtype; CRISPR-associated protein Cas5, N-terminal domain.
 
   
 0.870
rnc
RNAse III; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
      
 0.576
Toce_0524
CRISPR-associated protein, Csm1 family; COGs: COG1353 hydrolase of the HD superfamily (permuted catalytic motifs); InterPro IPR000160:IPR013408; KEGG: ate:Athe_2704 metal dependent phosphohydrolase; SPTR: Metal dependent phosphohydrolase; TIGRFAM: CRISPR-associated protein, Csm1 family; PFAM: HD domain; TIGRFAM: CRISPR-associated protein, Csm1 family.
 
   
 0.523
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: medium (52%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.