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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Toce_0249COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310:IPR016059; KEGG: swo:Swol_1123 DNA ligase, putative; PFAM: ATP dependent DNA ligase; SPTR: DNA ligase, putative; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain. (308 aa)    
Predicted Functional Partners:
Toce_0250
DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR014145:IPR002755; KEGG: swo:Swol_1124 hypothetical protein; PFAM: DNA primase small subunit; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain.
  
 0.999
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
  
 0.988
Toce_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
   
 0.979
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.914
Toce_1394
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR004013:IPR002054:IPR003583:IPR003141:IPR 002008; KEGG: gbm:Gbem_0265 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; SPTR: PHP domain protein; PFAM: PHP domain.
  
 0.914
Toce_1679
D-proline reductase (dithiol); KEGG: cbf:CLI_3802 glycine/sarcosine/betaine reductase, component B, subunits alpha and beta; PRIAM: D-proline reductase (dithiol); SPTR: Glycine/sarcosine/betaine reductase, component B, subunits alpha and beta; PFAM: Glycine/sarcosine/betaine reductase component B subunits.
   
 0.852
Toce_1214
Metallophosphoesterase; COGs: COG0420 DNA repair exonuclease; InterPro IPR004843; KEGG: cth:Cthe_0945 metallophosphoesterase; PFAM: metallophosphoesterase; SPTR: Metallophosphoesterase; PFAM: Calcineurin-like phosphoesterase.
  
 0.843
Toce_1945
Helicase domain protein; InterPro IPR014001:IPR001650:IPR000330:IPR014021; KEGG: tex:Teth514_1830 helicase domain-containing protein; PFAM: helicase domain protein; SNF2-related protein; SMART: helicase domain protein; DEAD-like helicase; SPTR: Helicase domain protein; PFAM: Helicase conserved C-terminal domain; SNF2 family N-terminal domain.
   
 0.840
Toce_1211
KEGG: cth:Cthe_1092 hypothetical protein; SPTR: Putative uncharacterized protein.
   
 0.837
Toce_1213
SMC domain protein; COGs: COG0419 ATPase involved in DNA repair; InterPro IPR003395; KEGG: cth:Cthe_0944 SMC protein-like protein; PFAM: SMC domain protein; SPTR: SMC domain protein.
   
 0.837
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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