Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Toce_0250DNA polymerase LigD, polymerase domain protein; COGs: COG3285 eukaryotic-type DNA primase; InterPro IPR014145:IPR002755; KEGG: swo:Swol_1124 hypothetical protein; PFAM: DNA primase small subunit; SPTR: Putative uncharacterized protein; TIGRFAM: DNA polymerase LigD, polymerase domain protein; TIGRFAM: DNA ligase D; DNA polymerase LigD, polymerase domain. (297 aa)    
Predicted Functional Partners:
Toce_0249
COGs: COG1793 ATP-dependent DNA ligase; InterPro IPR012310:IPR016059; KEGG: swo:Swol_1123 DNA ligase, putative; PFAM: ATP dependent DNA ligase; SPTR: DNA ligase, putative; PFAM: ATP dependent DNA ligase domain; ATP dependent DNA ligase C terminal region; TIGRFAM: DNA polymerase LigD, ligase domain.
  
 0.999
ku
DNA end-binding protein Ku; With LigD forms a non-homologous end joining (NHEJ) DNA repair enzyme, which repairs dsDNA breaks with reduced fidelity. Binds linear dsDNA with 5'- and 3'- overhangs but not closed circular dsDNA nor ssDNA. Recruits and stimulates the ligase activity of LigD. Belongs to the prokaryotic Ku family.
 
  
 0.935
Toce_1394
PHP domain protein; COGs: COG1796 DNA polymerase IV (family X); InterProIPR004013:IPR002054:IPR003583:IPR003141:IPR 002008; KEGG: gbm:Gbem_0265 PHP domain protein; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; DNA polymerase X; Helix-hairpin-helix DNA-binding class 1; SPTR: PHP domain protein; PFAM: PHP domain.
     
 0.507
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
     
 0.507
Toce_0251
COGs: COG0644 Dehydrogenase (flavoprotein); InterPro IPR003953:IPR003042; KEGG: nth:Nther_1774 FAD dependent oxidoreductase; PFAM: fumarate reductase/succinate dehydrogenase flavoprotein domain protein; SPTR: FAD dependent oxidoreductase; PFAM: FAD binding domain.
       0.486
Toce_0464
Protein of unknown function DUF72; COGs: COG1801 conserved hypothetical protein; InterPro IPR002763; KEGG: mta:Moth_0268 hypothetical protein; PFAM: protein of unknown function DUF72; SPTR: Putative uncharacterized protein; PFAM: Protein of unknown function DUF72.
 
    0.420
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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