| node1 | node2 | node1 annotation | node2 annotation | score |
| Toce_0369 | Toce_0370 | COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | 0.999 |
| Toce_0369 | Toce_0371 | COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | 0.578 |
| Toce_0369 | Toce_0372 | COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | 0.430 |
| Toce_0370 | Toce_0369 | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | 0.999 |
| Toce_0370 | Toce_0371 | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | 0.607 |
| Toce_0370 | Toce_0372 | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | 0.818 |
| Toce_0370 | Toce_1588 | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | COGs: COG0438 Glycosyltransferase; InterProIPR001296:IPR013216:IPR001173:IPR019734:IPR 013026:IPR000276; KEGG: tnp:Tnap_0554 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; Methyltransferase type 11; glycosyl transferase group 1; SMART: Tetratricopeptide repeat; SPTR: Glycosyl transferase family 2; PFAM: Methyltransferase domain; Glycosyl transferases group 1; Glycosyl transferase family 2. | 0.527 |
| Toce_0371 | Toce_0369 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | 0.578 |
| Toce_0371 | Toce_0370 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | 0.607 |
| Toce_0371 | Toce_0372 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | 0.634 |
| Toce_0371 | Toce_0487 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | O-antigen polymerase; InterPro IPR019734:IPR013026:IPR007016; KEGG: tte:TTE0644 TPR repeat-containing protein; PFAM: O-antigen polymerase; SPTR: TPR-repeat-containing proteins; PFAM: O-Antigen ligase. | 0.544 |
| Toce_0371 | Toce_0502 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | Nucleotide sugar dehydrogenase; COGs: COG1004 UDP-glucose 6-dehydrogenase; InterPro IPR017476:IPR001732:IPR014026:IPR014027; KEGG: mtp:Mthe_0952 UDP-glucose 6-dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase; UDP-glucose/GDP-mannose dehydrogenase dimerisation; UDP-glucose/GDP-mannose dehydrogenase; PRIAM: UDP-glucose 6-dehydrogenase; SPTR: Nucleotide sugar dehydrogenase subfamily protein; TIGRFAM: nucleotide sugar dehydrogenase; PFAM: UDP-glucose/GDP-mannose dehydrogenase family, NAD binding domain; UDP-glucose/GDP-mannose dehydrogenase family, central domain; UDP-glucose/GDP [...] | 0.406 |
| Toce_0371 | Toce_1168 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | TPR repeat-containing protein; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR019734:IPR001440:IPR013026; KEGG: mth:MTH72 O-linked GlcNAc transferase; PFAM: TPR repeat-containing protein; SPTR: O-linked GlcNAc transferase; PFAM: Coatomer epsilon subunit; Tetratricopeptide repeat. | 0.798 |
| Toce_0371 | Toce_1588 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | COGs: COG0438 Glycosyltransferase; InterProIPR001296:IPR013216:IPR001173:IPR019734:IPR 013026:IPR000276; KEGG: tnp:Tnap_0554 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; Methyltransferase type 11; glycosyl transferase group 1; SMART: Tetratricopeptide repeat; SPTR: Glycosyl transferase family 2; PFAM: Methyltransferase domain; Glycosyl transferases group 1; Glycosyl transferase family 2. | 0.697 |
| Toce_0371 | Toce_2276 | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | COGs: COG1192 ATPase involved in chromosome partitioning; KEGG: cth:Cthe_2377 chromosome segregation ATPase; SPTR: Chromosome segregation ATPase; PFAM: CobQ/CobB/MinD/ParA nucleotide binding domain. | 0.772 |
| Toce_0372 | Toce_0369 | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | COGs: COG4585 Signal transduction histidine kinase; InterProIPR005467:IPR016381:IPR003594:IPR008595:IPR 011712; KEGG: tte:TTE1682 sensory transduction histidine kinase; PFAM: Sensor DegS domain protein; histidine kinase dimerisation and phosphoacceptor region; ATP-binding region ATPase domain protein; SMART: ATP-binding region ATPase domain protein; SPTR: Sensor protein DegS; PFAM: Histidine kinase; Sensor protein DegS; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase. | 0.430 |
| Toce_0372 | Toce_0370 | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | Two component transcriptional regulator, LuxR family; COGs: COG2197 Response regulator containing a CheY-like receiver domain and an HTH DNA-binding domain; InterPro IPR000792:IPR001789; KEGG: cth:Cthe_1267 two component LuxR family transcriptional regulator; PFAM: response regulator receiver; regulatory protein LuxR; SMART: response regulator receiver; regulatory protein LuxR; SPTR: Two component transcriptional regulator, LuxR family; PFAM: Response regulator receiver domain; Bacterial regulatory proteins, luxR family; TIGRFAM: RNA polymerase sigma factor, sigma-70 family. | 0.818 |
| Toce_0372 | Toce_0371 | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | KEGG: pth:PTH_2758 hypothetical protein; SPTR: Hypothetical membrane protein. | 0.634 |
| Toce_0372 | Toce_0487 | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | O-antigen polymerase; InterPro IPR019734:IPR013026:IPR007016; KEGG: tte:TTE0644 TPR repeat-containing protein; PFAM: O-antigen polymerase; SPTR: TPR-repeat-containing proteins; PFAM: O-Antigen ligase. | 0.447 |
| Toce_0372 | Toce_1168 | Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain. | TPR repeat-containing protein; COGs: COG3063 Tfp pilus assembly protein PilF; InterPro IPR019734:IPR001440:IPR013026; KEGG: mth:MTH72 O-linked GlcNAc transferase; PFAM: TPR repeat-containing protein; SPTR: O-linked GlcNAc transferase; PFAM: Coatomer epsilon subunit; Tetratricopeptide repeat. | 0.525 |