Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
Toce_0384thiamineS protein; InterPro IPR003749; KEGG: chy:CHY_1711 hypothetical protein; PFAM: thiamineS protein; SPTR: Putative uncharacterized protein; PFAM: ThiS family. (76 aa)    
Predicted Functional Partners:
moaC
GTP cyclohydrolase subunit MoaC; Catalyzes the conversion of (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP); Belongs to the MoaC family.
  
  
 0.935
Toce_0732
UBA/THIF-type NAD/FAD binding protein; COGs: COG0476 Dinucleotide-utilizing protein involved in molybdopterin and thiamine biosynthesis family 2; InterPro IPR000594:IPR007901; KEGG: mta:Moth_1970 UBA/ThiF-type NAD/FAD binding fold; PFAM: UBA/THIF-type NAD/FAD binding protein; MoeZ/MoeB domain protein; SPTR: UBA/THIF-type NAD/FAD binding fold; PFAM: MoeZ/MoeB domain; ThiF family.
  
 
 0.859
Toce_0276
Molybdenum cofactor synthesis domain protein; COGs: COG0521 Molybdopterin biosynthesis protein; InterPro IPR020817:IPR005302:IPR001453:IPR008284; KEGG: ddf:DEFDS_0070 hypothetical protein; PFAM: molybdopterin binding domain; MOSC domain containing protein; SPTR: Putative uncharacterized protein; TIGRFAM: molybdenum cofactor synthesis domain protein; PFAM: MOSC domain; Probable molybdopterin binding domain; TIGRFAM: molybdenum cofactor synthesis domain.
  
  
 0.829
moaA
GTP cyclohydrolase subunit MoaA; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
  
 0.787
Toce_0383
COGs: COG2414 Aldehyde:ferredoxin oxidoreductase; InterPro IPR013983:IPR001203; KEGG: chy:CHY_1712 aldehyde ferredoxin oxidoreductase, tungsten-containing; PFAM: aldehyde ferredoxin oxidoreductase; Aldehyde ferredoxin oxidoreductase; PRIAM: Aldehyde ferredoxin oxidoreductase; SMART: Aldehyde ferredoxin oxidoreductase; SPTR: Aldehyde ferredoxin oxidoreductase, tungsten-containing; PFAM: Aldehyde ferredoxin oxidoreductase, N-terminal domain; Aldehyde ferredoxin oxidoreductase, domains 2 & 3.
       0.619
Toce_0382
Fe-S-cluster; COGs: COG0437 Fe-S-cluster-containing hydrogenase components 1; InterPro IPR017896:IPR017900; KEGG: pth:PTH_0486 Fe-S-cluster; SPTR: Fe-S-cluster; PFAM: 4Fe-4S binding domain.
     
 0.615
Toce_0711
Cystathionine beta-synthase (acetylserine-dependent); COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001216:IPR001926; KEGG: gtn:GTNG_2474 O-acetylserine lyase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase; cysteine synthase A; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.585
Toce_0731
COGs: COG0031 Cysteine synthase; InterPro IPR005856:IPR005859:IPR001216:IPR001926; KEGG: mta:Moth_1706 cysteine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Cysteine synthase; TIGRFAM: cysteine synthase A; cysteine synthase; PFAM: Pyridoxal-phosphate dependent enzyme; TIGRFAM: cysteine synthase A; cysteine synthases; Belongs to the cysteine synthase/cystathionine beta- synthase family.
  
 
 0.585
Toce_1487
Pyridoxal-5'-phosphate-dependent protein beta subunit; COGs: COG0031 Cysteine synthase; InterPro IPR001926; KEGG: tte:TTE1236 threonine synthase; PFAM: Pyridoxal-5'-phosphate-dependent protein beta subunit; SPTR: Threonine synthase; PFAM: Pyridoxal-phosphate dependent enzyme.
  
 
 0.585
Toce_0243
FAD-dependent pyridine nucleotide-disulfide oxidoreductase; COGs: COG3383 Uncharacterized anaerobic dehydrogenase; InterProIPR001041:IPR013027:IPR006963:IPR006656:IPR 000759:IPR017900:IPR006655:IPR017896; KEGG: aoe:Clos_0277 molybdopterin oxidoreductase; PFAM: FAD-dependent pyridine nucleotide-disulphide oxidoreductase; ferredoxin; molybdopterin oxidoreductase Fe4S4 region; molybdopterin oxidoreductase; SPTR: Molybdopterin oxidoreductase; PFAM: Pyridine nucleotide-disulphide oxidoreductase; Molybdopterin oxidoreductase; Molybdopterin oxidoreductase Fe4S4 domain; TIGRFAM: glutamate synt [...]
  
  
 0.551
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (14%) [HD]