Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Toce_0385Transcriptional regulator, IclR family; COGs: COG1414 Transcriptional regulator; InterPro IPR005471:IPR014757; KEGG: mta:Moth_1780 IclR family transcriptional regulator; PFAM: Transcriptional regulator IclR; regulatory protein IclR; SMART: regulatory protein IclR; SPTR: Transcriptional regulator, IclR family; PFAM: IclR helix-turn-helix domain; Bacterial transcriptional regulator. (261 aa)    
Predicted Functional Partners:
Toce_1841
COGs: COG2049 Allophanate hydrolase subunit 1; InterPro IPR010016:IPR003833; KEGG: tpd:Teth39_1158 allophanate hydrolase subunit 1; PFAM: Allophanate hydrolase subunit 1; SMART: Allophanate hydrolase subunit 1; SPTR: Allophanate hydrolase subunit 1; PFAM: Allophanate hydrolase subunit 1; TIGRFAM: conserved hypothetical protein TIGR00370.
  
    0.753
Toce_1840
Urea amidolyase related protein; COGs: COG1984 Allophanate hydrolase subunit 2; InterPro IPR003778; KEGG: tpd:Teth39_1159 UreA amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; PRIAM: Urea carboxylase; SMART: Allophanate hydrolase subunit 2; SPTR: Urea amidolyase related protein; TIGRFAM: urea amidolyase related protein; PFAM: Allophanate hydrolase subunit 2; TIGRFAM: biotin-dependent carboxylase uncharacterized domain.
  
  
 0.735
Toce_0387
1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: cth:Cthe_0368 NCAIR mutase (PurE)-related protein; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: NCAIR mutase (PurE)-related protein; PFAM: AIR carboxylase.
       0.688
Toce_0386
PP-loop domain protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232:IPR011063; KEGG: chy:CHY_1281 hypothetical protein; PFAM: PP-loop domain protein; SPTR: ExsB family protein; PFAM: NAD synthase; TIGRFAM: conserved hypothetical protein TIGR00268.
       0.686
larC
Protein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family.
       0.686
gltX
glutamyl-tRNA synthetase; Catalyzes the attachment of glutamate to tRNA(Glu) in a two- step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu); Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.
       0.541
Toce_1846
Conserved hypothetical protein; COGs: COG1914 Mn2+ and Fe2+ transporter of the NRAMP family; InterPro IPR005779; KEGG: hypothetical protein; SPTR: YcsG; PFAM: Natural resistance-associated macrophage protein.
  
  
 0.504
pxpA
LamB/YcsF family protein; Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.
  
  
 0.491
Toce_0384
thiamineS protein; InterPro IPR003749; KEGG: chy:CHY_1711 hypothetical protein; PFAM: thiamineS protein; SPTR: Putative uncharacterized protein; PFAM: ThiS family.
       0.451
Toce_0381
Benzoate transporter; COGs: COG3135 Uncharacterized protein involved in benzoate metabolism; InterPro IPR003016:IPR004711; KEGG: mta:Moth_1772 benzoate transporter; PFAM: Benzoate membrane transport protein; SPTR: Benzoate transporter; TIGRFAM: benzoate transporter; PFAM: Benzoate membrane transport protein; TIGRFAM: benzoate transporter.
 
   
 0.441
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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