Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Toce_0386PP-loop domain protein; COGs: COG1606 ATP-utilizing protein of the PP-loop superfamily; InterPro IPR005232:IPR011063; KEGG: chy:CHY_1281 hypothetical protein; PFAM: PP-loop domain protein; SPTR: ExsB family protein; PFAM: NAD synthase; TIGRFAM: conserved hypothetical protein TIGR00268. (278 aa)    
Predicted Functional Partners:
larC
Protein of unknown function DUF111; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family.
 
 0.998
Toce_0387
1-(5-phosphoribosyl)-5-amino-4-imidazole- carboxylate (AIR) carboxylase; COGs: COG1691 NCAIR mutase (PurE)-related protein; InterPro IPR000031; KEGG: cth:Cthe_0368 NCAIR mutase (PurE)-related protein; PFAM: 1-(5-phosphoribosyl)-5-amino-4-imidazole-carboxylate (AIR) carboxylase; SPTR: NCAIR mutase (PurE)-related protein; PFAM: AIR carboxylase.
  
 0.997
Toce_2224
Protein of unknown function DUF2088; COGs: COG3875 conserved hypothetical protein; InterPro IPR018657; KEGG: amt:Amet_0538 hypothetical protein; PFAM: Protein of unknown function DUF2088; SPTR: Putative uncharacterized protein; PFAM: Uncharacterized conserved protein (DUF2088).
 
  
 0.903
Toce_0663
PP-loop domain protein; COGs: COG0037 ATPase of the PP-loop superfamily protein implicated in cell cycle control; InterPro IPR012089:IPR011063; KEGG: dau:Daud_0882 PP-loop domain-containing protein; PFAM: PP-loop domain protein; SPTR: PP-loop domain protein; PFAM: PP-loop family; Belongs to the TtcA family.
 
    0.839
mnmA
tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase; Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.
    
 0.789
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
 
    0.739
Toce_0585
Cobalt ABC transporter, inner membrane subunit CbiQ; COGs: COG0619 ABC-type cobalt transport system permease component CbiQ and related transporter; InterPro IPR012809:IPR003339; KEGG: pth:PTH_1655 ABC-type cobalt transport system, permease component CbiQ and related transporters; PFAM: cobalt transport protein; SPTR: ABC-type cobalt transport system, permease component CbiQ and related transporters; TIGRFAM: cobalt ABC transporter, inner membrane subunit CbiQ; PFAM: Cobalt transport protein; TIGRFAM: cobalt ABC transporter, permease protein CbiQ.
  
    0.703
Toce_0936
COGs: COG0328 Ribonuclease HI; InterPro IPR002156; KEGG: aoe:Clos_1283 ribonuclease H; PFAM: ribonuclease H; SPTR: Ribonuclease H; PFAM: RNase H.
 
      0.700
Toce_0385
Transcriptional regulator, IclR family; COGs: COG1414 Transcriptional regulator; InterPro IPR005471:IPR014757; KEGG: mta:Moth_1780 IclR family transcriptional regulator; PFAM: Transcriptional regulator IclR; regulatory protein IclR; SMART: regulatory protein IclR; SPTR: Transcriptional regulator, IclR family; PFAM: IclR helix-turn-helix domain; Bacterial transcriptional regulator.
       0.686
cbiM
Cobalamin biosynthesis protein CbiM; Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import.
  
    0.653
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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