Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Toce_0473COGs: COG2206 HD-GYP domain; InterPro IPR000160:IPR006674; KEGG: nth:Nther_2110 diguanylate cyclase and metal dependent phosphohydrolase; PFAM: GGDEF domain containing protein; metal-dependent phosphohydrolase HD sub domain; SMART: GGDEF domain containing protein; SPTR: Diguanylate cyclase and metal dependent phosphohydrolase; TIGRFAM: diguanylate cyclase; PFAM: HD domain; GGDEF domain; TIGRFAM: PAS domain S-box; diguanylate cyclase (GGDEF) domain. (480 aa)    
Predicted Functional Partners:
cheB
Response regulator receiver modulated CheB methylesterase; Involved in chemotaxis. Part of a chemotaxis signal transduction system that modulates chemotaxis in response to various stimuli. Catalyzes the demethylation of specific methylglutamate residues introduced into the chemoreceptors (methyl-accepting chemotaxis proteins or MCP) by CheR. Also mediates the irreversible deamidation of specific glutamine residues to glutamic acid. Belongs to the CheB family.
  
 
 0.807
Toce_0372
Diguanylate cyclase; COGs: COG3706 Response regulator containing a CheY-like receiver domain and a GGDEF domain; InterPro IPR000160:IPR003018; KEGG: tte:TTE2335 diguanylate cyclase/phosphodiesterase; PFAM: GGDEF domain containing protein; GAF domain protein; PRIAM: Diguanylate kinase; SMART: GGDEF domain containing protein; GAF domain protein; SPTR: Diguanylate cyclase/phosphodiesterase domain 1 (GGDEF); TIGRFAM: diguanylate cyclase; PFAM: GAF domain; GGDEF domain; TIGRFAM: diguanylate cyclase (GGDEF) domain.
 
 
0.797
Toce_2010
COGs: COG4786 Flagellar basal body rod protein; InterProIPR019776:IPR020013:IPR012834:IPR001444:IPR 010930; KEGG: aoe:Clos_2549 hypothetical protein; PFAM: protein of unknown function DUF1078 domain protein; flagellar basal body rod protein; SPTR: Putative uncharacterized protein; TIGRFAM: flagellar basal-body rod protein FlgG; fagellar hook-basal body protein; PFAM: Domain of unknown function (DUF1078); Flagella basal body rod protein; TIGRFAM: flagellar basal-body rod protein FlgB; fagellar hook-basal body proteins; flagellar basal-body rod protein FlgG, Gram-negative bacteria.
   
 
 0.789
Toce_2011
COGs: COG4786 Flagellar basal body rod protein; InterProIPR019776:IPR020013:IPR012836:IPR001444:IPR 010930; KEGG: tte:TTE0172 flagellar basal body and hook proteins; PFAM: flagellar basal body rod protein; protein of unknown function DUF1078 domain protein; SPTR: Putative uncharacterized protein; TIGRFAM: flagellar basal-body rod protein FlgF; fagellar hook-basal body protein; PFAM: Domain of unknown function (DUF1078); Flagella basal body rod protein; TIGRFAM: flagellar basal-body rod protein FlgF; fagellar hook-basal body proteins.
   
 
 0.789
Toce_1588
COGs: COG0438 Glycosyltransferase; InterProIPR001296:IPR013216:IPR001173:IPR019734:IPR 013026:IPR000276; KEGG: tnp:Tnap_0554 glycosyl transferase family 2; PFAM: glycosyl transferase family 2; Methyltransferase type 11; glycosyl transferase group 1; SMART: Tetratricopeptide repeat; SPTR: Glycosyl transferase family 2; PFAM: Methyltransferase domain; Glycosyl transferases group 1; Glycosyl transferase family 2.
   
 
 0.729
Toce_0192
COGs: COG1215 Glycosyltransferase probably involved in cell wall biogenesis; KEGG: mta:Moth_1831 glycosyltransferase; SPTR: Glycosyltransferase.
  
  
 0.572
spoIIAB
Putative anti-sigma regulatory factor, serine/threonine protein kinase; Binds to sigma F and blocks its ability to form an RNA polymerase holoenzyme (E-sigma F). Phosphorylates SpoIIAA on a serine residue. This phosphorylation may enable SpoIIAA to act as an anti- anti-sigma factor that counteracts SpoIIAB and thus releases sigma F from inhibition.
  
 
 0.543
Toce_1543
ATP-binding region ATPase domain protein; InterPro IPR003594; KEGG: mta:Moth_0388 putative anti-sigma regulatory factor (serine/threonine protein kinase); PFAM: ATP-binding region ATPase domain protein; SPTR: Putative anti-sigma regulatory factor (Serine/threonine protein kinase); PFAM: Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase.
  
 
 0.543
Toce_0460
Response regulator receiver protein; COGs: COG0784 FOG: CheY-like receiver; InterPro IPR001789:IPR013972; KEGG: cbe:Cbei_4174 response regulator receiver; PFAM: YcbB domain protein; response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver; PFAM: Response regulator receiver domain; YcbB domain.
  
  
 0.541
Toce_1106
MotA/TolQ/ExbB proton channel; COGs: COG1291 Flagellar motor component; InterPro IPR002898:IPR000540; KEGG: nth:Nther_1402 MotA/TolQ/ExbB proton channel; PFAM: MotA/TolQ/ExbB proton channel; SPTR: MotA/TolQ/ExbB proton channel; PFAM: MotA/TolQ/ExbB proton channel family.
 
  
 0.537
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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