Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Toce_0522HEPN domain protein; COGs: COG2250 conserved hypothetical protein related to C-terminal domain of eukaryotic chaperone SACSIN; InterPro IPR007842; KEGG: dth:DICTH_0449 HEPN domain, putative; PFAM: HEPN domain protein; SMART: HEPN domain protein; SPTR: Hepn domain, putative; PFAM: HEPN domain. (130 aa)    
Predicted Functional Partners:
Toce_0523
DNA polymerase beta domain protein region; InterPro IPR002934; KEGG: dth:DICTH_0448 nucleotidyltransferase domain, putative; PFAM: DNA polymerase beta domain protein region; SPTR: Nucleotidyltransferase domain, putative; PFAM: Nucleotidyltransferase domain.
       0.794
Toce_0213
DNA polymerase beta domain protein region; InterPro IPR002934; KEGG: chy:CHY_1716 nucleotidyltransferase/HEPN domain-containing protein; PFAM: DNA polymerase beta domain protein region; SPTR: Nucleotidyltransferase/HEPN domain protein; PFAM: Nucleotidyltransferase domain.
 
 
   0.710
Toce_0543
HEPN domain protein; COGs: COG2250 conserved hypothetical protein related to C-terminal domain of eukaryotic chaperone SACSIN; InterPro IPR007842; KEGG: tye:THEYE_A1691 HEPN domain, putative; PFAM: HEPN domain protein; SMART: HEPN domain protein; SPTR: Hepn domain, putative; PFAM: HEPN domain.
  
     0.575
Toce_0520
Transcriptional modulator of MazE/toxin, MazF; COGs: COG2337 Growth inhibitor; InterPro IPR003477; KEGG: gka:GK1648 ppGpp-regulated growth inhibitor (ChpA/MazF); PFAM: PemK family protein; SPTR: PpGpp-regulated growth inhibitor (ChpA/MazF); manually curated; PFAM: PemK-like protein.
       0.485
Toce_0521
Transcriptional regulator/antitoxin, MazE; COGs: COG2336 Growth regulator; InterPro IPR007159; KEGG: gyc:GYMC61_2489 transcriptional regulator/antitoxin, MazE; PFAM: SpoVT/AbrB domain protein; SPTR: Suppressor of ppGpp-regulated growth inhibitor (ChpA/MazF); PFAM: SpoVT / AbrB like domain.
       0.485
Toce_0682
InterPro IPR002934; KEGG: rrs:RoseRS_4091 DNA polymerase beta subunit; PFAM: DNA polymerase beta domain protein region; SPTR: DNA polymerase, beta domain protein region; PFAM: Nucleotidyltransferase domain.
 
     0.472
Toce_0524
CRISPR-associated protein, Csm1 family; COGs: COG1353 hydrolase of the HD superfamily (permuted catalytic motifs); InterPro IPR000160:IPR013408; KEGG: ate:Athe_2704 metal dependent phosphohydrolase; SPTR: Metal dependent phosphohydrolase; TIGRFAM: CRISPR-associated protein, Csm1 family; PFAM: HD domain; TIGRFAM: CRISPR-associated protein, Csm1 family.
       0.438
Toce_0525
InterPro IPR010149; KEGG: csc:Csac_0076 CRISPR-associated Csm2 family protein; PFAM: CRISPR-associated protein TM1810 domain protein; SPTR: CRISPR-associated protein, Csm2 family; TIGRFAM: CRISPR-associated protein, Csm2 family; PFAM: Protein of unknown function (DUF310); TIGRFAM: CRISPR-associated protein, Csm2 family.
       0.423
Toce_0526
CRISPR-associated protein, Csm3 family; COGs: COG1337 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR013412:IPR005537; KEGG: csc:Csac_0077 CRISPR-associated RAMP Csm3 family protein; PFAM: protein of unknown function DUF324; SPTR: CRISPR-associated RAMP protein, Csm3 family; TIGRFAM: CRISPR-associated RAMP protein, Csm3 family; PFAM: RAMP superfamily; TIGRFAM: CRISPR-associated RAMP protein, Csm3 family.
       0.404
Toce_0527
CRISPR-associated RAMP protein, Csm4 family; COGs: COG1567 Uncharacterized protein predicted to be involved in DNA repair (RAMP superfamily); InterPro IPR005510:IPR005537; KEGG: tme:Tmel_1673 CRISPR-associated RAMP Csm4 family protein; PFAM: protein of unknown function DUF324; SPTR: CRISPR-associated RAMP protein, Csm4 family; TIGRFAM: CRISPR-associated RAMP protein, Csm4 family; PFAM: RAMP superfamily; TIGRFAM: CRISPR-associated RAMP protein, Csm4 family.
       0.404
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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