Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
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Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
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Toce_0539COGs: COG0383 Alpha-mannosidase; InterPro IPR000602:IPR011682; KEGG: tit:Thit_0527 glycoside hydrolase family 38; PFAM: glycoside hydrolase family 38; glycosyl hydrolase 38 domain protein; PRIAM: Alpha-mannosidase; SPTR: Glycoside hydrolase family 38; PFAM: Glycosyl hydrolases family 38 C-terminal domain; Glycosyl hydrolases family 38 N-terminal domain. (876 aa)    
Predicted Functional Partners:
Toce_1742
Two component transcriptional regulator, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterProIPR001789:IPR000005:IPR020449:IPR018060:IPR 018062; KEGG: tit:Thit_0428 two component transcriptional regulator, AraC family; PFAM: response regulator receiver; helix-turn-helix- domain containing protein AraC type; SMART: response regulator receiver; Helix-turn-helix, AraC domain; SPTR: Two component transcriptional regulator, AraC family; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix pro [...]
 
    0.687
Toce_2123
ATPase AAA-2 domain protein; COGs: COG0542 ATPase with chaperone activity ATP-binding subunit; InterProIPR003593:IPR018368:IPR001270:IPR004176:IPR 003959:IPR001943:IPR013093:IPR019489; KEGG: tte:TTE2327 ATPase with chaperone activity, ATP-binding subunit; PFAM: ATPase AAA-2 domain protein; Clp domain protein; AAA ATPase central domain protein; UvrB/UvrC protein; Clp ATPase-like; SMART: AAA ATPase; SPTR: ATPases with chaperone activity, ATP-binding subunit; PFAM: AAA domain (Cdc48 subfamily); C-terminal, D2-small domain, of ClpB protein; Clp amino terminal domain; ATPase family associat [...]
   
  
 0.674
Toce_0345
6-phospho-beta-glucosidase; COGs: COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase family 4 of glycosyl hydrolase; InterPro IPR019802:IPR001088; KEGG: tte:TTE0337 alpha-galactosidase/6-phospho-beta-glucosidase; PFAM: glycoside hydrolase family 4; SPTR: Alpha-galactosidases/6-phospho-beta-glucosidases, family 4 of glycosyl hydrolases; PFAM: Family 4 glycosyl hydrolase; Family 4 glycosyl hydrolase C-terminal domain.
 
   
 0.629
Toce_0538
FeS cluster assembly scaffold protein NifU; COGs: COG0822 NifU homolog involved in Fe-S cluster formation; InterPro IPR017787:IPR002871; KEGG: mta:Moth_1651 nitrogen-fixing NifU-like; PFAM: nitrogen-fixing NifU domain protein; SPTR: Nitrogen-fixing NifU-like; TIGRFAM: FeS cluster assembly scaffold protein NifU; PFAM: NifU-like N terminal domain; TIGRFAM: FeS cluster assembly scaffold protein NifU, Clostridium type.
       0.628
Toce_1700
Glycoside hydrolase family 4; COGs: COG1486 Alpha-galactosidase/6-phospho-beta-glucosidase family 4 of glycosyl hydrolase; InterPro IPR001088; KEGG: amt:Amet_4185 glycoside hydrolase family protein; PFAM: glycoside hydrolase family 4; SPTR: Glycoside hydrolase, family 4; PFAM: Family 4 glycosyl hydrolase; Family 4 glycosyl hydrolase C-terminal domain.
 
   
 0.621
Toce_0546
Two component transcriptional regulator, AraC family; COGs: COG4753 Response regulator containing CheY-like receiver domain and AraC-type DNA-binding domain; InterProIPR018060:IPR001789:IPR018062:IPR000005:IPR 020449; KEGG: tex:Teth514_1958 response regulator receiver protein; PFAM: response regulator receiver; helix-turn-helix- domain containing protein AraC type; SMART: response regulator receiver; Helix-turn-helix, AraC domain; SPTR: Response regulator receiver protein; PFAM: Response regulator receiver domain; Bacterial regulatory helix-turn-helix proteins, AraC family.
  
    0.618
Toce_1111
COGs: COG2204 Response regulator containing CheY-like receiver AAA-type ATPase and DNA-binding domains; InterPro IPR001789; KEGG: hmo:HM1_2237 response regulator receiver domain; PFAM: response regulator receiver; SMART: response regulator receiver; SPTR: Response regulator receiver domain; PFAM: Response regulator receiver domain.
  
    0.618
rpoA
DNA-directed RNA polymerase subunit alpha; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
    
   0.529
Toce_0541
Transcriptional antiterminator, BglG; COGs: COG3711 Transcriptional antiterminator; InterProIPR001034:IPR002178:IPR013011:IPR011608:IPR 007737; KEGG: tit:Thit_0523 PTS modulated transcriptional regulator, MtlR family; PFAM: PRD domain protein; M trans-acting positive regulator; phosphoenolpyruvate-dependent sugar phosphotransferase system EIIA 2; PRIAM: Protein-N(pi)-phosphohistidine--sugar phosphotransferase; SPTR: PTS modulated transcriptional regulator, MtlR family; PFAM: Mga helix-turn-helix domain; HTH domain; PRD domain; PTS system, Lactose/Cellobiose specific IIB subunit; Phosph [...]
 
  
 0.489
cmk
COGs: COG0283 Cytidylate kinase; InterPro IPR008243:IPR000623:IPR011994:IPR003136; KEGG: tit:Thit_1145 cytidylate kinase; PFAM: cytidylate kinase region; Chorismate mutase of the AroH class; shikimate kinase; SPTR: Cytidylate kinase; TIGRFAM: cytidylate kinase; chorismate mutase; PFAM: Cytidylate kinase; Chorismate mutase type I; TIGRFAM: cytidylate kinase; monofunctional chorismate mutase, gram positive type, clade 1.
  
    0.477
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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