STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pdxA4-hydroxythreonine-4-phosphate dehydrogenase; COGs: COG1995 Pyridoxal phosphate biosynthesis protein; InterPro IPR005255; KEGG: tpd:Teth39_1674 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; PRIAM: 4-hydroxythreonine-4-phosphate dehydrogenase; SPTR: 4-hydroxythreonine-4-phosphate dehydrogenase; TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; PFAM: Pyridoxal phosphate biosynthetic protein PdxA; TIGRFAM: 4-hydroxythreonine-4-phosphate dehydrogenase; Belongs to the PdxA family. (326 aa)    
Predicted Functional Partners:
Toce_0653
COGs: COG3395 conserved hypothetical protein; InterPro IPR010737; KEGG: tpd:Teth39_1675 type III effector Hrp-dependent outers; PFAM: type III effector Hrp-dependent outers; SPTR: Type III effector Hrp-dependent outers; PFAM: Protein of unknown function, DUF1537.
     0.996
Toce_0652
InterPro IPR004684; KEGG: tpd:Teth39_1676 2-keto-3-deoxygluconate permease; PFAM: 2-keto-3-deoxygluconate permease; SPTR: 2-keto-3-deoxygluconate permease; PFAM: 2-keto-3-deoxygluconate permease; TIGRFAM: 2-keto-3-deoxygluconate transporter.
 
     0.948
gyrB
DNA gyrase subunit B; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.
 
      0.850
rsmA
Dimethyladenosine transferase; Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits.
 
  
 0.799
Toce_0650
SAF domain protein; COGs: COG2721 Altronate dehydratase; InterPro IPR013974; KEGG: tpd:Teth39_1678 SAF domain-containing protein; PFAM: SAF domain protein; SPTR: SAF domain; PFAM: SAF domain.
       0.741
Toce_0651
COGs: COG2721 Altronate dehydratase; InterPro IPR007392; KEGG: tpd:Teth39_1677 altronate dehydratase; PFAM: D-galactarate dehydratase/Altronate hydrolase domain protein; PRIAM: Altronate dehydratase; SPTR: Altronate dehydratase; PFAM: D-galactarate dehydratase / Altronate hydrolase, C terminus.
       0.741
ribBA
GTP cyclohydrolase II; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the C-terminal section; belongs to the GTP cyclohydrolase II family.
  
  
 0.660
dapA
Dihydrodipicolinate synthase; Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).
 
  
 0.620
Toce_0649
Proprionate catabolism activator, Fis family; COGs: COG3829 Transcriptional regulator containing PAS AAA-type ATPase and DNA-binding domains; InterProIPR000014:IPR003593:IPR002078:IPR020441:IPR 010524:IPR013767:IPR002197; KEGG: tpd:Teth39_1679 sigma-54 dependent trancsriptional regulator; PFAM: sigma-54 factor interaction domain-containing protein; Propionate catabolism activator domain protein; PAS fold domain protein; helix-turn-helix Fis-type; SMART: AAA ATPase; PAS domain containing protein; SPTR: Sigma54 specific transcriptional regulator, Fis family; TIGRFAM: PAS sensor protein; [...]
 
     0.542
Toce_0647
Predicted D-glycerate permease (TC 2.A.8.1.6); COGs: COG2610 H+/gluconate symporter and related permease; InterPro IPR003474; KEGG: mta:Moth_0895 gluconate transporter; PFAM: Gluconate transporter; SPTR: Gluconate transporter; PFAM: GntP family permease; TIGRFAM: gluconate transporter.
       0.486
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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