Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Toce_0666Recombination protein MgsA; COGs: COG2256 ATPase related to the helicase subunit of the Holliday junction resolvase; InterPro IPR003593:IPR003959; KEGG: tpd:Teth39_0710 recombination factor protein RarA; PFAM: AAA ATPase central domain protein; SMART: AAA ATPase; SPTR: AAA ATPase central domain protein; PFAM: MgsA AAA+ ATPase C terminal; Holliday junction DNA helicase ruvB N-terminus. (446 aa)    
Predicted Functional Partners:
Toce_0002
DNA polymerase III, beta subunit; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
    
 
 0.813
Toce_0667
ABC transporter, ATPase, predicted; COGs: COG3044 ATPase of the ABC class; InterPro IPR019195; KEGG: tit:Thit_0992 ABC transporter, ATPase, predicted; PFAM: ABC transporter, ATPase, predicted; SPTR: ATPase of the ABC class-like protein; PFAM: Predicted ATPase of the ABC class.
       0.773
Toce_0665
COGs: COG1254 Acylphosphatase; InterPro IPR001792:IPR017968; KEGG: tte:TTE1765 acylphosphatase; PFAM: acylphosphatase; SPTR: Acylphosphatase; PFAM: Acylphosphatase.
       0.750
Toce_1223
DNA translocase FtsK; COGs: COG1674 DNA segregation ATPase FtsK/SpoIIIE and related protein; InterPro IPR003593:IPR002543:IPR018541; KEGG: pth:PTH_1293 DNA segregation ATPase FtsK/SpoIIIE and related proteins; PFAM: cell divisionFtsK/SpoIIIE; DNA translocase ftsK gamma; SMART: AAA ATPase; SPTR: DNA segregation ATPase FtsK/SpoIIIE and related proteins; PFAM: Ftsk gamma domain; FtsK/SpoIIIE family.
 
  
 0.677
Toce_0664
COGs: COG2008 Threonine aldolase; InterPro IPR001597; KEGG: tte:TTE0267 threonine aldolase; PFAM: aromatic amino acid beta-eliminating lyase/threonine aldolase; SPTR: Threonine aldolase; PFAM: Beta-eliminating lyase.
       0.599
polA
DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.
 
   
 0.540
Toce_1029
Sun protein; Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA.
 
  
 0.538
cinA
Competence/damage-inducible protein cinA; COGs: COG1058 nucleotide-utilizing enzyme related to molybdopterin-biosynthesis enzyme MoeA; InterPro IPR001453:IPR008136:IPR008135; KEGG: dtu:Dtur_0064 competence/damage-inducible protein CinA; PFAM: CinA domain protein; molybdopterin binding domain; SPTR: CinA-like protein; TIGRFAM: competence/damage-inducible protein CinA; PFAM: Probable molybdopterin binding domain; Competence-damaged protein; TIGRFAM: competence/damage-inducible protein CinA N-terminal domain; competence/damage-inducible protein CinA C-terminal domain; molybdenum cofactor [...]
     
 0.484
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
 
 0.483
aroK
3-dehydroquinate dehydratase, type II; Catalyzes a trans-dehydration via an enolate intermediate. Belongs to the shikimate kinase family.
 
     0.465
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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