| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Toce_0706 | Toce_0796 | Toce_0706 | Toce_0796 | Methyltransferase cognate corrinoid protein; COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759:IPR012741; KEGG: swo:Swol_0418 cobalamin-dependent methionine synthase, B12-binding; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; SPTR: Dimethylamine corrinoid protein; TIGRFAM: methyltransferase cognate corrinoid protein; PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | 0.977 |
| Toce_0790 | Toce_0796 | Toce_0790 | Toce_0796 | COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759; KEGG: amt:Amet_2093 cobalamin B12-binding domain-containing protein; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; SPTR: Cobalamin B12-binding domain protein; PFAM: B12 binding domain. | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | 0.977 |
| Toce_0793 | Toce_0796 | Toce_0793 | Toce_0796 | COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759; KEGG: amt:Amet_2097 cobalamin B12-binding domain-containing protein; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; SPTR: Cobalamin B12-binding domain protein; PFAM: B12 binding domain. | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | 0.977 |
| Toce_0796 | Toce_0706 | Toce_0796 | Toce_0706 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | Methyltransferase cognate corrinoid protein; COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759:IPR012741; KEGG: swo:Swol_0418 cobalamin-dependent methionine synthase, B12-binding; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; SPTR: Dimethylamine corrinoid protein; TIGRFAM: methyltransferase cognate corrinoid protein; PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. | 0.977 |
| Toce_0796 | Toce_0790 | Toce_0796 | Toce_0790 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759; KEGG: amt:Amet_2093 cobalamin B12-binding domain-containing protein; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; SPTR: Cobalamin B12-binding domain protein; PFAM: B12 binding domain. | 0.977 |
| Toce_0796 | Toce_0793 | Toce_0796 | Toce_0793 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG5012 cobalamin binding protein; InterPro IPR006158:IPR003759; KEGG: amt:Amet_2097 cobalamin B12-binding domain-containing protein; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; SPTR: Cobalamin B12-binding domain protein; PFAM: B12 binding domain. | 0.977 |
| Toce_0796 | Toce_0807 | Toce_0796 | Toce_0807 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.963 |
| Toce_0796 | Toce_0810 | Toce_0796 | Toce_0810 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein); InterPro IPR016041; KEGG: amt:Amet_2025 acetyl-CoA decarbonylase/synthase complex subunit delta; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit. | 0.992 |
| Toce_0796 | Toce_0811 | Toce_0796 | Toce_0811 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); InterPro IPR016218:IPR007202:IPR016041; KEGG: amt:Amet_2026 acetyl-CoA decarbonylase/synthase complex subunit gamma; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Fe-S cluster domain protein; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit; PFAM: Putative Fe-S cluster; CO dehydrogenase/acetyl-CoA synthase delta subunit. | 0.994 |
| Toce_0796 | Toce_0813 | Toce_0796 | Toce_0813 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit; InterPro IPR004461; KEGG: cdl:CDR20291_0655 putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; SPTR: Putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, beta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit. | 0.968 |
| Toce_0796 | Toce_1078 | Toce_0796 | Toce_1078 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | Methyltransferase cognate corrinoid protein; COGs: COG5012 cobalamin binding protein; InterPro IPR003759:IPR006158:IPR012741; KEGG: mta:Moth_1208 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; PRIAM: Methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine S-methyltransferase; TIGRFAM: methyltransferase cognate corrinoid protein; PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. | 0.978 |
| Toce_0796 | Toce_1081 | Toce_0796 | Toce_1081 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dhd:Dhaf_0077 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylene-tetrahydrofolate reductase C terminal; Methylenetetrahydrofolate reductase. | 0.971 |
| Toce_0796 | fhs | Toce_0796 | Toce_0802 | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | Formate-tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: ckr:CKR_0385 hypothetical protein; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | 0.941 |
| Toce_0807 | Toce_0796 | Toce_0807 | Toce_0796 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Dihydropteroate synthase DHPS; COGs: COG1410 Methionine synthase I cobalamin-binding domain; InterPro IPR000489; KEGG: amt:Amet_2092 methyltetrahydrofolate:corrinoid/iron-sulfur protein methyltransferase; PFAM: dihydropteroate synthase DHPS; SPTR: Dihydropteroate synthase, DHPS; PFAM: Pterin binding enzyme. | 0.963 |
| Toce_0807 | Toce_0810 | Toce_0807 | Toce_0810 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG2069 CO dehydrogenase/acetyl-CoA synthase delta subunit (corrinoid Fe-S protein); InterPro IPR016041; KEGG: amt:Amet_2025 acetyl-CoA decarbonylase/synthase complex subunit delta; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit. | 0.999 |
| Toce_0807 | Toce_0811 | Toce_0807 | Toce_0811 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG1456 CO dehydrogenase/acetyl-CoA synthase gamma subunit (corrinoid Fe-S protein); InterPro IPR016218:IPR007202:IPR016041; KEGG: amt:Amet_2026 acetyl-CoA decarbonylase/synthase complex subunit gamma; PFAM: CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel; Fe-S cluster domain protein; SPTR: CO dehydrogenase/acetyl-CoA synthase delta subunit; PFAM: Putative Fe-S cluster; CO dehydrogenase/acetyl-CoA synthase delta subunit. | 0.992 |
| Toce_0807 | Toce_0813 | Toce_0807 | Toce_0813 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG1614 CO dehydrogenase/acetyl-CoA synthase beta subunit; InterPro IPR004461; KEGG: cdl:CDR20291_0655 putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; SPTR: Putative carbon monoxide dehydrogenase/acetyl-CoA synthase complex, beta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit; PFAM: CO dehydrogenase/acetyl-CoA synthase complex beta subunit; TIGRFAM: CO dehydrogenase/acetyl-CoA synthase complex, beta subunit. | 0.991 |
| Toce_0807 | Toce_1078 | Toce_0807 | Toce_1078 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Methyltransferase cognate corrinoid protein; COGs: COG5012 cobalamin binding protein; InterPro IPR003759:IPR006158:IPR012741; KEGG: mta:Moth_1208 5-methyltetrahydrofolate--homocysteine S-methyltransferase; PFAM: cobalamin B12-binding domain protein; Methionine synthase B12-binding module cap domain protein; PRIAM: Methionine synthase; SPTR: 5-methyltetrahydrofolate--homocysteine S-methyltransferase; TIGRFAM: methyltransferase cognate corrinoid protein; PFAM: B12 binding domain; TIGRFAM: methyltransferase cognate corrinoid proteins, Methanosarcina family. | 0.904 |
| Toce_0807 | Toce_1081 | Toce_0807 | Toce_1081 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: dhd:Dhaf_0077 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylene-tetrahydrofolate reductase C terminal; Methylenetetrahydrofolate reductase. | 0.917 |
| Toce_0807 | fhs | Toce_0807 | Toce_0802 | COGs: COG0685 5 10-methylenetetrahydrofolate reductase; InterPro IPR003171; KEGG: amt:Amet_2022 methylenetetrahydrofolate reductase; PFAM: methylenetetrahydrofolate reductase; SPTR: Methylenetetrahydrofolate reductase; PFAM: Methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Formate-tetrahydrofolate ligase; COGs: COG2759 Formyltetrahydrofolate synthetase; InterPro IPR020628:IPR000559; KEGG: ckr:CKR_0385 hypothetical protein; PFAM: formate-tetrahydrofolate ligase FTHFS; PRIAM: Formate--tetrahydrofolate ligase; SPTR: Formate--tetrahydrofolate ligase; PFAM: Formate--tetrahydrofolate ligase. | 0.811 |