close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hprKHpr(Ser) kinase/phosphatase; Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable car [...] (308 aa)    
Predicted Functional Partners:
Toce_0866
COGs: COG1925 Phosphotransferase system HPr-related protein; InterPro IPR000032:IPR005698:IPR001020:IPR002114; KEGG: tte:TTE1820 phosphotransferase system, HPr-related proteins; PFAM: phosphoryl transfer system HPr; SPTR: Phosphotransferase system, HPr-related proteins; TIGRFAM: phosphocarrier, HPr family; PFAM: PTS HPr component phosphorylation site; TIGRFAM: Phosphotransferase System HPr (HPr) Family.
 
 
 
 0.887
Toce_0846
Bifunctional phosphoglucose/phosphomannose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR011857:IPR001347:IPR019490; KEGG: ate:Athe_0619 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; sugar isomerase (SIS); PRIAM: Mannose-6-phosphate isomerase; SPTR: Mannose-6-phosphate isomerase / glucose-6-phosphate isomerase; TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bacterial phospho-glucose isomerase C-terminal region; SIS domain; TIGRFAM: bifunctional phosphoglucose/p [...]
     
 0.788
uvrB
Excinuclease ABC subunit B; The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate [...]
    
 0.773
Toce_0847
PHP domain protein; COGs: COG1387 Histidinol phosphatase and related hydrolase of the PHP family; InterPro IPR003141:IPR004013; KEGG: tte:TTE1963 putative hydrolase; PFAM: PHP domain protein; SMART: phosphoesterase PHP domain protein; SPTR: Putative PHP domain protein; PFAM: PHP domain.
       0.697
Toce_0848
D-amino acid aminotransferase; Acts on the D-isomers of alanine, leucine, aspartate, glutamate, aminobutyrate, norvaline and asparagine. The enzyme transfers an amino group from a substrate D-amino acid to the pyridoxal phosphate cofactor to form pyridoxamine and an alpha-keto acid in the first half-reaction.
     
 0.658
Toce_1427
Phosphoenolpyruvate--protein phosphotransferase; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 
   
 0.638
nagB
Glucosamine-6-phosphate isomerase; Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.
  
  
 0.626
Toce_1032
COGs: COG0515 Serine/threonine protein kinase; InterProIPR020635:IPR002290:IPR005543:IPR017442:IPR 017441:IPR008271:IPR000719; KEGG: tpd:Teth39_1313 serine/threonine protein kinase with PASTA sensor(s); PFAM: Serine/threonine-protein kinase-like domain; PASTA domain containing protein; SMART: serine/threonine protein kinase; Tyrosine-protein kinase, catalytic domain; PASTA domain containing protein; SPTR: Serine/threonine protein kinase with PASTA sensor(S); PFAM: Protein kinase domain; PASTA domain.
   
 
 0.607
Toce_1809
Glucokinase, ROK family; COGs: COG1940 Transcriptional regulator/sugar kinase; InterPro IPR004654:IPR000600; KEGG: tte:TTE0090 transcriptional regulator; PFAM: ROK family protein; SPTR: ROK family protein (Putative glucokinase); TIGRFAM: glucokinase, ROK family; PFAM: ROK family; TIGRFAM: ROK family protein (putative glucokinase).
     
 0.560
Toce_0844
Protein of unknown function DUF1540; InterPro IPR011437; KEGG: cac:CAC0521 hypothetical protein; PFAM: protein of unknown function DUF1540; SPTR: Putative uncharacterized protein; PFAM: Domain of Unknown Function (DUF1540).
       0.546
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.