Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
Toce_0871COGs: COG0469 Pyruvate kinase; InterProIPR001697:IPR018209:IPR015793:IPR015794:IPR 008279; KEGG: tte:TTE1815 pyruvate kinase; PFAM: Pyruvate kinase barrel; Pyruvate kinase alpha/beta; PEP-utilising protein mobile region; SPTR: Pyruvate kinase; TIGRFAM: pyruvate kinase; PFAM: Pyruvate kinase, barrel domain; PEP-utilising enzyme, mobile domain; Pyruvate kinase, alpha/beta domain; TIGRFAM: pyruvate kinase; Belongs to the pyruvate kinase family. (584 aa)    
Predicted Functional Partners:
pfkA
6-phosphofructokinase; Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.
 
 
 0.999
eno
Enolase; Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis; Belongs to the enolase family.
 
 0.998
Toce_0846
Bifunctional phosphoglucose/phosphomannose isomerase; COGs: COG0166 Glucose-6-phosphate isomerase; InterPro IPR011857:IPR001347:IPR019490; KEGG: ate:Athe_0619 bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bifunctional glucose-6-phosphate/mannose-6-phosphate isomerase-like; sugar isomerase (SIS); PRIAM: Mannose-6-phosphate isomerase; SPTR: Mannose-6-phosphate isomerase / glucose-6-phosphate isomerase; TIGRFAM: bifunctional phosphoglucose/phosphomannose isomerase; PFAM: Bacterial phospho-glucose isomerase C-terminal region; SIS domain; TIGRFAM: bifunctional phosphoglucose/p [...]
  
 0.997
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. Belongs to the LDH/MDH superfamily. LDH family.
  
 0.995
Toce_1827
Malic protein NAD-binding protein; COGs: COG0281 Malic enzyme; InterPro IPR012301:IPR012302:IPR015884; KEGG: tex:Teth514_0830 malate dehydrogenase; PFAM: malic protein NAD-binding; malic protein domain protein; SPTR: Malate dehydrogenase (Oxaloacetate-decarboxylating) (NADP(+)); PFAM: Malic enzyme, NAD binding domain; Malic enzyme, N-terminal domain.
  
 0.975
rplF
LSU ribosomal protein L6P; This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center; Belongs to the universal ribosomal protein uL6 family.
  
 
 0.969
pgk
COGs: COG0126 3-phosphoglycerate kinase; InterPro IPR001576:IPR015911; KEGG: tpd:Teth39_0732 phosphoglycerate kinase; PFAM: phosphoglycerate kinase; PRIAM: Phosphoglycerate kinase; SPTR: Phosphoglycerate kinase; PFAM: Phosphoglycerate kinase; Belongs to the phosphoglycerate kinase family.
 
 
 0.969
rpsB
COGs: COG0052 Ribosomal protein S2; InterPro IPR005706:IPR001865:IPR018130; KEGG: gka:GK1249 30S ribosomal protein S2; PFAM: ribosomal protein S2; SPTR: 30S ribosomal protein S2; TIGRFAM: ribosomal protein S2; PFAM: Ribosomal protein S2; TIGRFAM: ribosomal protein S2, bacterial type; Belongs to the universal ribosomal protein uS2 family.
  
 
 0.968
Toce_1810
COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771:IPR011289; KEGG: csc:Csac_1189 fructose-1,6-bisphosphate aldolase, class II; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Fructose-bisphosphate aldolase; SPTR: Fructose-bisphosphate aldolase; TIGRFAM: fructose-1,6-bisphosphate aldolase, class II; ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases; fructose-1,6-bisphosphate aldolase, class II, various bacterial and amitochondriate protist.
  
 0.959
Toce_1875
COGs: COG0191 Fructose/tagatose bisphosphate aldolase; InterPro IPR000771; KEGG: str:Sterm_0504 ketose-bisphosphate aldolase; PFAM: ketose-bisphosphate aldolase class-II; PRIAM: Tagatose-bisphosphate aldolase; SPTR: Putative uncharacterized protein; TIGRFAM: ketose-bisphosphate aldolase; PFAM: Fructose-bisphosphate aldolase class-II; TIGRFAM: ketose-bisphosphate aldolases.
  
 0.959
Your Current Organism:
Thermosediminibacter oceani
NCBI taxonomy Id: 555079
Other names: T. oceani DSM 16646, Thermosediminibacter oceani DSM 16646, Thermosediminibacter oceani JW/IW-1228P, Thermosediminibacter oceani str. DSM 16646, Thermosediminibacter oceani strain DSM 16646
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